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- W2488341016 abstract "The use of monoclonal antibodies directed against the tumor cell surface to carry toxic moieties specifically to cancer cells remains an attractive approach towards more selective anti-tumor therapy. In constructing immunotoxins, the disulfide bond between the two subunits in ricin is reduced by treatment with mercaptoethanol, and the chains are separated by affinity chromatography. Purified A chain is coupled to a chemically introduced sulfhydryl moiety on the monoclonal antibody via a disulfide bond, thus mimicking the native toxin. The new composite molecule retains the specificity of the antibody and the potent toxic activity of the A chain. Immunotoxins are cytotoxic only to cells expressing the appropriate antigen. The utility of constructing immunotoxins with antibody directed against the carcinoembryonic antigen (CEA) has been explored. CEA is a tumor-associated antigen of adult human solid malignancies. This antigen is present on the cell membrane of many adult cancers, particularly colorectal cancers, and in the fetal intestine." @default.
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- W2488341016 title "Enhancement of the Specific Cytotoxicity of Anti-Carcinoembryonic Antigen Immunotoxins by Adenovirus and Carboxylic Ionophores" @default.
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