Matches in SemOpenAlex for { <https://semopenalex.org/work/W2488347978> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2488347978 abstract "Despite the biological and clinical importance of blood clot contraction, it is a poorly understood mechanical process driven by forces that are generated by platelets and propagated by fibrin, resulting in the compression and deformation of red blood cells (RBCs) and the overall volume shrinkage of the clot. Optical tracking and dynamic rheometry were used to examine unconstrained (free to reduce volume) and constrained (fixed volume) clot contraction over time, which allowed for the kinetics of clot contraction and generation of contractile force to be tracked. The presence of RBCs enhanced the generation of platelet contractile forces by 60% but lessened the rate and extent of clot contraction by 30% when compared to samples without RBCs. Structurally, blood clots have distinct areas showing fibrin and RBCs in association with platelets and areas where they spatially removed from platelets. We developed a three-element active poroviscoelastic model to improve the understanding of how composition and distribution of the clot, particularly the presence of RBCs, affects the process of clot contraction. Our model revealed that clot response to contraction was not the result of poroelastic behavior, due to the diffusion limit, but rather resulted from the active contraction of a viscoelastic material. Platelets contract in series and parallel to the RBCs and fibrin placing them under compressive and tensile forces. Their resistance results in a shift in the stall stress of the system and an increase in the overall contractile force generated by platelets. Collectively, these results reveal that the incorporation of mechanically passive RBCs cells into the fibrin network structure can strongly influence the contractile response of mechanically active platelets and the overall contraction. This model presents potential to elucidate the mechanism through which RBC volume and/or mechanical stiffness affects the process of clot contraction." @default.
- W2488347978 created "2016-08-23" @default.
- W2488347978 creator A5007009397 @default.
- W2488347978 creator A5011906405 @default.
- W2488347978 creator A5031069096 @default.
- W2488347978 creator A5081919310 @default.
- W2488347978 creator A5089911552 @default.
- W2488347978 date "2016-02-01" @default.
- W2488347978 modified "2023-09-28" @default.
- W2488347978 title "Active Dynamic Mechanics of Blood Clot Contraction" @default.
- W2488347978 doi "https://doi.org/10.1016/j.bpj.2015.11.1642" @default.
- W2488347978 hasPublicationYear "2016" @default.
- W2488347978 type Work @default.
- W2488347978 sameAs 2488347978 @default.
- W2488347978 citedByCount "1" @default.
- W2488347978 countsByYear W24883479782021 @default.
- W2488347978 crossrefType "journal-article" @default.
- W2488347978 hasAuthorship W2488347978A5007009397 @default.
- W2488347978 hasAuthorship W2488347978A5011906405 @default.
- W2488347978 hasAuthorship W2488347978A5031069096 @default.
- W2488347978 hasAuthorship W2488347978A5081919310 @default.
- W2488347978 hasAuthorship W2488347978A5089911552 @default.
- W2488347978 hasBestOaLocation W24883479781 @default.
- W2488347978 hasConcept C12554922 @default.
- W2488347978 hasConcept C126322002 @default.
- W2488347978 hasConcept C136229726 @default.
- W2488347978 hasConcept C159985019 @default.
- W2488347978 hasConcept C163415756 @default.
- W2488347978 hasConcept C185592680 @default.
- W2488347978 hasConcept C186541917 @default.
- W2488347978 hasConcept C191172559 @default.
- W2488347978 hasConcept C192562407 @default.
- W2488347978 hasConcept C203014093 @default.
- W2488347978 hasConcept C2777292125 @default.
- W2488347978 hasConcept C2778863912 @default.
- W2488347978 hasConcept C54173615 @default.
- W2488347978 hasConcept C71924100 @default.
- W2488347978 hasConcept C86803240 @default.
- W2488347978 hasConcept C89560881 @default.
- W2488347978 hasConceptScore W2488347978C12554922 @default.
- W2488347978 hasConceptScore W2488347978C126322002 @default.
- W2488347978 hasConceptScore W2488347978C136229726 @default.
- W2488347978 hasConceptScore W2488347978C159985019 @default.
- W2488347978 hasConceptScore W2488347978C163415756 @default.
- W2488347978 hasConceptScore W2488347978C185592680 @default.
- W2488347978 hasConceptScore W2488347978C186541917 @default.
- W2488347978 hasConceptScore W2488347978C191172559 @default.
- W2488347978 hasConceptScore W2488347978C192562407 @default.
- W2488347978 hasConceptScore W2488347978C203014093 @default.
- W2488347978 hasConceptScore W2488347978C2777292125 @default.
- W2488347978 hasConceptScore W2488347978C2778863912 @default.
- W2488347978 hasConceptScore W2488347978C54173615 @default.
- W2488347978 hasConceptScore W2488347978C71924100 @default.
- W2488347978 hasConceptScore W2488347978C86803240 @default.
- W2488347978 hasConceptScore W2488347978C89560881 @default.
- W2488347978 hasLocation W24883479781 @default.
- W2488347978 hasOpenAccess W2488347978 @default.
- W2488347978 hasPrimaryLocation W24883479781 @default.
- W2488347978 hasRelatedWork W1443488559 @default.
- W2488347978 hasRelatedWork W1758465088 @default.
- W2488347978 hasRelatedWork W1990693205 @default.
- W2488347978 hasRelatedWork W1999239587 @default.
- W2488347978 hasRelatedWork W2001023332 @default.
- W2488347978 hasRelatedWork W2085429349 @default.
- W2488347978 hasRelatedWork W2288291991 @default.
- W2488347978 hasRelatedWork W2323757848 @default.
- W2488347978 hasRelatedWork W2489217339 @default.
- W2488347978 hasRelatedWork W2562534433 @default.
- W2488347978 hasRelatedWork W2562956960 @default.
- W2488347978 hasRelatedWork W2727558726 @default.
- W2488347978 hasRelatedWork W2769324061 @default.
- W2488347978 hasRelatedWork W2793654403 @default.
- W2488347978 hasRelatedWork W2943846229 @default.
- W2488347978 hasRelatedWork W3080366006 @default.
- W2488347978 hasRelatedWork W635452242 @default.
- W2488347978 hasRelatedWork W2249393381 @default.
- W2488347978 hasRelatedWork W2739796966 @default.
- W2488347978 hasRelatedWork W92990839 @default.
- W2488347978 isParatext "false" @default.
- W2488347978 isRetracted "false" @default.
- W2488347978 magId "2488347978" @default.
- W2488347978 workType "article" @default.