Matches in SemOpenAlex for { <https://semopenalex.org/work/W2488381803> ?p ?o ?g. }
- W2488381803 endingPage "2552" @default.
- W2488381803 startingPage "2543" @default.
- W2488381803 abstract "ABSTRACT Previous studies have demonstrated that E proteins induce activation-induced deaminase (AID) expression in activated B cells. Here, we examined the role of Id3 in germinal center (GC) cells. We found that Id3 expression is high in follicular B lineage cells but declines in GC cells. Immunized mice with Id3 expression depleted displayed a block in germinal center B cell maturation, showed reduced numbers of marginal zone B cells and class-switched cells, and were associated with decreased antibody titers and lower numbers of plasma cells. In vitro , Id3-depleted B cells displayed a defect in class switch recombination. Whereas AID levels were not altered in Id3-depleted activated B cells, the expression of a subset of genes encoding signaling components of antigen receptor-, cytokine receptor-, and chemokine receptor-mediated signaling was significantly impaired. We propose that during the GC reaction, Id3 levels decline to activate the expression of genes encoding signaling components that mediate B cell receptor- and or cytokine receptor-mediated signaling to promote the differentiation of GC B cells." @default.
- W2488381803 created "2016-08-23" @default.
- W2488381803 creator A5014551477 @default.
- W2488381803 creator A5019800530 @default.
- W2488381803 creator A5064852230 @default.
- W2488381803 creator A5081339238 @default.
- W2488381803 creator A5084622181 @default.
- W2488381803 creator A5085824896 @default.
- W2488381803 date "2016-10-15" @default.
- W2488381803 modified "2023-10-12" @default.
- W2488381803 title "Id3 Orchestrates Germinal Center B Cell Development" @default.
- W2488381803 cites W1563678561 @default.
- W2488381803 cites W1579102917 @default.
- W2488381803 cites W1832299245 @default.
- W2488381803 cites W1912001164 @default.
- W2488381803 cites W1965662580 @default.
- W2488381803 cites W1971329821 @default.
- W2488381803 cites W1984228266 @default.
- W2488381803 cites W1993090087 @default.
- W2488381803 cites W1995635569 @default.
- W2488381803 cites W1997516537 @default.
- W2488381803 cites W2001049701 @default.
- W2488381803 cites W2014993834 @default.
- W2488381803 cites W2015782236 @default.
- W2488381803 cites W2020818536 @default.
- W2488381803 cites W2021880506 @default.
- W2488381803 cites W2034648844 @default.
- W2488381803 cites W2057812734 @default.
- W2488381803 cites W2058722357 @default.
- W2488381803 cites W2066555099 @default.
- W2488381803 cites W2070745300 @default.
- W2488381803 cites W2073566510 @default.
- W2488381803 cites W2080082308 @default.
- W2488381803 cites W2082670705 @default.
- W2488381803 cites W2082849113 @default.
- W2488381803 cites W2086928171 @default.
- W2488381803 cites W2087021490 @default.
- W2488381803 cites W2118028844 @default.
- W2488381803 cites W2118139064 @default.
- W2488381803 cites W2122713601 @default.
- W2488381803 cites W2123836839 @default.
- W2488381803 cites W2124649657 @default.
- W2488381803 cites W2124796057 @default.
- W2488381803 cites W2125983166 @default.
- W2488381803 cites W2127754056 @default.
- W2488381803 cites W2128410841 @default.
- W2488381803 cites W2136892614 @default.
- W2488381803 cites W2148878836 @default.
- W2488381803 cites W2159511823 @default.
- W2488381803 cites W2165608602 @default.
- W2488381803 cites W2169456326 @default.
- W2488381803 cites W2172155558 @default.
- W2488381803 cites W2179438025 @default.
- W2488381803 cites W4246504300 @default.
- W2488381803 doi "https://doi.org/10.1128/mcb.00150-16" @default.
- W2488381803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5038142" @default.
- W2488381803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27457619" @default.
- W2488381803 hasPublicationYear "2016" @default.
- W2488381803 type Work @default.
- W2488381803 sameAs 2488381803 @default.
- W2488381803 citedByCount "23" @default.
- W2488381803 countsByYear W24883818032017 @default.
- W2488381803 countsByYear W24883818032018 @default.
- W2488381803 countsByYear W24883818032019 @default.
- W2488381803 countsByYear W24883818032020 @default.
- W2488381803 countsByYear W24883818032021 @default.
- W2488381803 countsByYear W24883818032022 @default.
- W2488381803 countsByYear W24883818032023 @default.
- W2488381803 crossrefType "journal-article" @default.
- W2488381803 hasAuthorship W2488381803A5014551477 @default.
- W2488381803 hasAuthorship W2488381803A5019800530 @default.
- W2488381803 hasAuthorship W2488381803A5064852230 @default.
- W2488381803 hasAuthorship W2488381803A5081339238 @default.
- W2488381803 hasAuthorship W2488381803A5084622181 @default.
- W2488381803 hasAuthorship W2488381803A5085824896 @default.
- W2488381803 hasBestOaLocation W24883818031 @default.
- W2488381803 hasConcept C137756551 @default.
- W2488381803 hasConcept C153911025 @default.
- W2488381803 hasConcept C157695867 @default.
- W2488381803 hasConcept C159654299 @default.
- W2488381803 hasConcept C200180986 @default.
- W2488381803 hasConcept C203014093 @default.
- W2488381803 hasConcept C2775855021 @default.
- W2488381803 hasConcept C2776090121 @default.
- W2488381803 hasConcept C2778453870 @default.
- W2488381803 hasConcept C2778690821 @default.
- W2488381803 hasConcept C62478195 @default.
- W2488381803 hasConcept C67662055 @default.
- W2488381803 hasConcept C86803240 @default.
- W2488381803 hasConcept C8891405 @default.
- W2488381803 hasConcept C95444343 @default.
- W2488381803 hasConcept C96926380 @default.
- W2488381803 hasConceptScore W2488381803C137756551 @default.
- W2488381803 hasConceptScore W2488381803C153911025 @default.
- W2488381803 hasConceptScore W2488381803C157695867 @default.
- W2488381803 hasConceptScore W2488381803C159654299 @default.
- W2488381803 hasConceptScore W2488381803C200180986 @default.
- W2488381803 hasConceptScore W2488381803C203014093 @default.