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• W2488388549 endingPage "395" @default.
• W2488388549 startingPage "339" @default.
• W2488388549 abstract "This chapter discusses the contributions of particular organs and tissues to cholesterol synthesis in the whole organism, the manner in which cholesterol synthesis is regulated in different tissues, and the influence of various dietary, hormonal, and pharmacological agents on cholesterol synthesis at the tissue or cell level. Cholesterol synthesis may be measured in perfuse organs or in incubations of tissue slices, biopsy specimens, freshly isolated cells, cells in culture, or subcellular fractions of tissue homogenates. In the mature animal, the general effect of metabolic regulation is to maintain homeostasis within each tissue and within the body as a whole. Moreover, the regulation of metabolic processes in a multicellular organism may be thought of in terms of two levels of complexity—that of the individual cell and that of the organism as a whole. The regulatory mechanisms inherent in the cell itself are primitive, in the sense that they are generally to be found in unicellular organisms. In higher organisms, the primitive control mechanisms are modulated by substances, such as hormones that reach the cell from the external medium and whose actions serve to integrate the metabolism of different cells in the interests of the whole organism. In most animal tissues, the intracellular content of total cholesterol is determined by the rate of intracellular synthesis and the balance between the rates of transport of cholesterol into and out of the cell. Only in the liver and the steroid-hormone-forming organs catabolism plays a significant role in the overall metabolism of cholesterol." @default.
• W2488388549 created "2016-08-23" @default.
• W2488388549 creator A5080879968 @default.
• W2488388549 date "1981-01-01" @default.
• W2488388549 modified "2023-09-26" @default.
• W2488388549 title "Cholesterol Synthesis in Animal Tissues" @default.
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