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- W2488392688 endingPage "III" @default.
- W2488392688 startingPage "245" @default.
- W2488392688 abstract "Oral squamous cell carcinoma is believed to progress through sequential stages of premalignancies to invasive cancer. Once invasion takes place, prognosis is poor and mortality and morbidity rates are dismal. The application of molecular technology to samples can revolutionize the way in which oral mucosa regions with increased cancer risk are detected and managed. This chapter briefly discusses the limitations of the current approaches for identifying oral premalignant lesions (OPL). It is suggested that the old definition of OPLs be extended to include not only morphologically but also genetically altered tissue in which cancer is more likely to occur. For demonstrating how molecular markers can have an impact on clinical activities, the data obtained on OPLs using microsatellite analysis for loss of heterozygosity (LOH) are described. This approach can be used to identify those lesions that appear clinically and histologically benign, yet contain high-risk genetic alterations. It also provides an early indication of the recurrence of a cancer at a former oral cancer site and judges the efficacy of the treatment of OPLs. In addition, the potential use of exfoliated cells as a source for DNA for microsatellite analysis is discussed, with an indication of how such a noninvasive approach can be used to extend the ability to identify and manage regions of high risk. Data generated by this study can lead to a better understanding of the natural history of the development of aerodigestive tract cancer." @default.
- W2488392688 created "2016-08-23" @default.
- W2488392688 creator A5040861518 @default.
- W2488392688 creator A5041620962 @default.
- W2488392688 creator A5089589253 @default.
- W2488392688 date "2003-01-01" @default.
- W2488392688 modified "2023-09-25" @default.
- W2488392688 title "Molecular Markers of Oral Premalignant Lesion Risk" @default.
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