Matches in SemOpenAlex for { <https://semopenalex.org/work/W2488406175> ?p ?o ?g. }
- W2488406175 endingPage "52" @default.
- W2488406175 startingPage "31" @default.
- W2488406175 abstract "The dynamic addition and removal of covalent posttranslational modifications (PTMs) on histone proteins serves as a major mechanism regulating chromatin-templated biological processes in eukaryotic genomes. Histone PTMs and their combinations function by directly altering the physical structure of chromatin and as rheostats for effector protein interactions. In this chapter, we detail microarray-based methods for analyzing the substrate specificity of lysine methyltransferase and demethylase enzymes on immobilized synthetic histone peptides. Consistent with the histone code hypothesis, we reveal a strong influence of adjacent and, surprisingly, distant histone PTMs on the ability of histone-modifying enzymes to methylate or demethylate their substrates. This platform will greatly facilitate future investigations into histone substrate specificity and mechanisms of PTM signaling that regulate the catalytic properties of histone-modifying enzymes." @default.
- W2488406175 created "2016-08-23" @default.
- W2488406175 creator A5003630381 @default.
- W2488406175 creator A5004858655 @default.
- W2488406175 creator A5038761014 @default.
- W2488406175 creator A5050402883 @default.
- W2488406175 creator A5069297803 @default.
- W2488406175 creator A5084160097 @default.
- W2488406175 creator A5091496526 @default.
- W2488406175 date "2016-01-01" @default.
- W2488406175 modified "2023-10-16" @default.
- W2488406175 title "Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray" @default.
- W2488406175 cites W160911776 @default.
- W2488406175 cites W1617099866 @default.
- W2488406175 cites W1968190628 @default.
- W2488406175 cites W1974006656 @default.
- W2488406175 cites W1981259598 @default.
- W2488406175 cites W1985444222 @default.
- W2488406175 cites W1986501276 @default.
- W2488406175 cites W1995553979 @default.
- W2488406175 cites W1999337138 @default.
- W2488406175 cites W2000251389 @default.
- W2488406175 cites W2001891149 @default.
- W2488406175 cites W2002698073 @default.
- W2488406175 cites W2009858080 @default.
- W2488406175 cites W2028764523 @default.
- W2488406175 cites W2033581736 @default.
- W2488406175 cites W2041992457 @default.
- W2488406175 cites W2049482823 @default.
- W2488406175 cites W2051819385 @default.
- W2488406175 cites W2054643318 @default.
- W2488406175 cites W2055678358 @default.
- W2488406175 cites W2057321383 @default.
- W2488406175 cites W2063271327 @default.
- W2488406175 cites W2068157186 @default.
- W2488406175 cites W2076446466 @default.
- W2488406175 cites W2077981176 @default.
- W2488406175 cites W2079435272 @default.
- W2488406175 cites W2092794927 @default.
- W2488406175 cites W2094280432 @default.
- W2488406175 cites W2096083625 @default.
- W2488406175 cites W2101994612 @default.
- W2488406175 cites W2125765631 @default.
- W2488406175 cites W2131592995 @default.
- W2488406175 cites W2132373747 @default.
- W2488406175 cites W2141452262 @default.
- W2488406175 cites W2144792857 @default.
- W2488406175 cites W2155259040 @default.
- W2488406175 cites W2156371750 @default.
- W2488406175 cites W2159686118 @default.
- W2488406175 cites W2166346311 @default.
- W2488406175 cites W2205907925 @default.
- W2488406175 cites W2206849653 @default.
- W2488406175 cites W2414618913 @default.
- W2488406175 cites W2739174192 @default.
- W2488406175 cites W31033437 @default.
- W2488406175 cites W4212766227 @default.
- W2488406175 doi "https://doi.org/10.1016/bs.mie.2016.01.008" @default.
- W2488406175 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5322744" @default.
- W2488406175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27423856" @default.
- W2488406175 hasPublicationYear "2016" @default.
- W2488406175 type Work @default.
- W2488406175 sameAs 2488406175 @default.
- W2488406175 citedByCount "14" @default.
- W2488406175 countsByYear W24884061752016 @default.
- W2488406175 countsByYear W24884061752017 @default.
- W2488406175 countsByYear W24884061752018 @default.
- W2488406175 countsByYear W24884061752019 @default.
- W2488406175 countsByYear W24884061752021 @default.
- W2488406175 countsByYear W24884061752022 @default.
- W2488406175 countsByYear W24884061752023 @default.
- W2488406175 crossrefType "book-chapter" @default.
- W2488406175 hasAuthorship W2488406175A5003630381 @default.
- W2488406175 hasAuthorship W2488406175A5004858655 @default.
- W2488406175 hasAuthorship W2488406175A5038761014 @default.
- W2488406175 hasAuthorship W2488406175A5050402883 @default.
- W2488406175 hasAuthorship W2488406175A5069297803 @default.
- W2488406175 hasAuthorship W2488406175A5084160097 @default.
- W2488406175 hasAuthorship W2488406175A5091496526 @default.
- W2488406175 hasBestOaLocation W24884061752 @default.
- W2488406175 hasConcept C10058791 @default.
- W2488406175 hasConcept C101152365 @default.
- W2488406175 hasConcept C104317684 @default.
- W2488406175 hasConcept C150194340 @default.
- W2488406175 hasConcept C150425827 @default.
- W2488406175 hasConcept C167227067 @default.
- W2488406175 hasConcept C185592680 @default.
- W2488406175 hasConcept C190727270 @default.
- W2488406175 hasConcept C22709980 @default.
- W2488406175 hasConcept C2781364455 @default.
- W2488406175 hasConcept C552990157 @default.
- W2488406175 hasConcept C55493867 @default.
- W2488406175 hasConcept C56428682 @default.
- W2488406175 hasConcept C64927066 @default.
- W2488406175 hasConcept C70721500 @default.
- W2488406175 hasConcept C83640560 @default.
- W2488406175 hasConcept C84772758 @default.
- W2488406175 hasConcept C86803240 @default.