FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2488412382> ?p ?o ?g. }

• W2488412382 endingPage "668" @default.
• W2488412382 startingPage "656" @default.
• W2488412382 abstract "Paraquat is a nitrogen herbicide imposing severe organ toxicity in human leading to acute lung injury and heart failure. The present study was designed to examine the impact of ablation of the innate proinflammatory mediator toll-like receptor 4 (TLR4) in paraquat-induced cardiac contractile dysfunction and the underlying mechanisms involved with a focus on endoplasmic reticulum (ER) stress and apoptosis. Adult male wild-type (WT) and TLR4 knockout (TLR4-/- ) mice were challenged with paraquat (45 mg/kg, i.p.) for 48 h prior to the assessment of myocardial and cardiomyocyte sarcomere function, ER stress, apoptosis and inflammation. Acute paraquat challenge exerted myocardial functional and geometric alterations including enlarged left ventricular end systolic diameter (LVESD), reduced fractional shortening, decreased sarcomere shortening, maximal velocities of sarcomere shortening and relengthening associated with unchanged LV posterior wall thickness, septal thickness, LV end diastolic diameter (LVEDD), heart rate, sarcomere length, time-to-peak shortening and time-to-90% relengthening. Although TLR4 ablation did not affect mechanical properties in the heart, it significantly attenuated or ablated paraquat-induced cardiac contractile anomalies. Moreover, paraquat imposed overt ER stress, apoptosis and inflammation as evidenced by upregulation of Bip, CHOP, Caspase-3, -9, Bax, Bad, and IL-1β, phosphorylation of PERK, eIF2α and IΚB, as well as activation of the stress molecules ERK and p38, with unchanged Caspase-8, Bcl2, TNF-α, p53, HMGB1, MyD88 and phosphorylation of Akt, GSK3β and JNK, the effects of which were attenuated or negated by TLR4 knockout. Taken together, our results suggested that TLR4 ablation alleviated paraquat-induced myocardial contractile dysfunction possibly through attenuation of ER stress, apoptosis and inflammation. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 656-668, 2017." @default.
• W2488412382 created "2016-08-23" @default.
• W2488412382 creator A5007706452 @default.
• W2488412382 creator A5012206107 @default.
• W2488412382 creator A5022121149 @default.
• W2488412382 creator A5024786516 @default.
• W2488412382 creator A5032397876 @default.
• W2488412382 creator A5033684035 @default.
• W2488412382 creator A5045703368 @default.
• W2488412382 creator A5049264813 @default.
• W2488412382 creator A5057823204 @default.
• W2488412382 creator A5089030416 @default.
• W2488412382 date "2016-07-21" @default.
• W2488412382 modified "2023-10-14" @default.
• W2488412382 title "Toll-like receptor 4 ablation rescues against paraquat-triggered myocardial dysfunction: Role of ER stress and apoptosis" @default.
• W2488412382 cites W1754641721 @default.
• W2488412382 cites W1763518723 @default.
• W2488412382 cites W1778232194 @default.
• W2488412382 cites W1876724481 @default.
• W2488412382 cites W1927752963 @default.
• W2488412382 cites W1965842668 @default.
• W2488412382 cites W1968152307 @default.
• W2488412382 cites W1971723295 @default.
• W2488412382 cites W1973314641 @default.
• W2488412382 cites W1977949915 @default.
• W2488412382 cites W1979376504 @default.
• W2488412382 cites W1983833627 @default.
• W2488412382 cites W1987204479 @default.
• W2488412382 cites W1989374806 @default.
• W2488412382 cites W1996236557 @default.
• W2488412382 cites W2006569614 @default.
• W2488412382 cites W2009596540 @default.
• W2488412382 cites W2021766187 @default.
• W2488412382 cites W2025982107 @default.
• W2488412382 cites W2035666460 @default.
• W2488412382 cites W2039056890 @default.
• W2488412382 cites W2040371581 @default.
• W2488412382 cites W2043990301 @default.
• W2488412382 cites W2050163931 @default.
• W2488412382 cites W2052808841 @default.
• W2488412382 cites W2054215464 @default.
• W2488412382 cites W2074131627 @default.
• W2488412382 cites W2074627513 @default.
• W2488412382 cites W2079536916 @default.
• W2488412382 cites W2092807396 @default.
• W2488412382 cites W2103072277 @default.
• W2488412382 cites W2110292185 @default.
• W2488412382 cites W2122103893 @default.
• W2488412382 cites W2128747093 @default.
• W2488412382 cites W2133523105 @default.
• W2488412382 cites W2147697802 @default.
• W2488412382 cites W2165015710 @default.
• W2488412382 cites W2166007002 @default.
• W2488412382 cites W2171323879 @default.
• W2488412382 cites W2182087156 @default.
• W2488412382 cites W2211468961 @default.
• W2488412382 cites W3214706838 @default.
• W2488412382 cites W339764038 @default.
• W2488412382 cites W58671489 @default.
• W2488412382 cites W635977401 @default.
• W2488412382 cites W908095114 @default.
• W2488412382 cites W913690002 @default.
• W2488412382 doi "https://doi.org/10.1002/tox.22267" @default.
• W2488412382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27442881" @default.
• W2488412382 hasPublicationYear "2016" @default.
• W2488412382 type Work @default.
• W2488412382 sameAs 2488412382 @default.
• W2488412382 citedByCount "28" @default.
• W2488412382 countsByYear W24884123822017 @default.
• W2488412382 countsByYear W24884123822018 @default.
• W2488412382 countsByYear W24884123822019 @default.
• W2488412382 countsByYear W24884123822020 @default.
• W2488412382 countsByYear W24884123822021 @default.
• W2488412382 countsByYear W24884123822022 @default.
• W2488412382 countsByYear W24884123822023 @default.
• W2488412382 crossrefType "journal-article" @default.
• W2488412382 hasAuthorship W2488412382A5007706452 @default.
• W2488412382 hasAuthorship W2488412382A5012206107 @default.
• W2488412382 hasAuthorship W2488412382A5022121149 @default.
• W2488412382 hasAuthorship W2488412382A5024786516 @default.
• W2488412382 hasAuthorship W2488412382A5032397876 @default.
• W2488412382 hasAuthorship W2488412382A5033684035 @default.
• W2488412382 hasAuthorship W2488412382A5045703368 @default.
• W2488412382 hasAuthorship W2488412382A5049264813 @default.
• W2488412382 hasAuthorship W2488412382A5057823204 @default.
• W2488412382 hasAuthorship W2488412382A5089030416 @default.
• W2488412382 hasConcept C126322002 @default.
• W2488412382 hasConcept C134018914 @default.
• W2488412382 hasConcept C139447449 @default.
• W2488412382 hasConcept C158617107 @default.
• W2488412382 hasConcept C164027704 @default.
• W2488412382 hasConcept C185592680 @default.
• W2488412382 hasConcept C190283241 @default.
• W2488412382 hasConcept C207200792 @default.
• W2488412382 hasConcept C2776070231 @default.
• W2488412382 hasConcept C2776151105 @default.
• W2488412382 hasConcept C2776914184 @default.
• W2488412382 hasConcept C55493867 @default.

• next