Matches in SemOpenAlex for { <https://semopenalex.org/work/W2488445062> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2488445062 abstract "Increasing evidence shows mitochondrial DNA (mtDNA) genetics contribute to complex diseases like cancer, but the mechanisms responsible are mostly unknown. A new genetically engineered mouse model was created that contains nuclear DNA from one mouse strain and mtDNA from different mouse strain(s), designated Mitochondrial Nuclear Exchange (MNX). We have demonstrated that specific mtDNA-nDNA combinations could modify metastasis efficiency. The underlying mechanism is hypothesized to be due to mtDNA-driven changes in nDNA expression, but how mtDNA regulates the coordinated gene expression is not yet known. Since DNA methylation is an important epigenetic modification that occurs in all vertebrate genomes and retrograde and anterograde cross-talk exists between the nuclear and mitochondrial genomes, we hypothesized that the nuclear epigenome, specifically methylation, changes as a result of mitochondrial haplotype. To test this hypothesis, we performed Meth-Seq using the Agilent Mouse SureSelectXT, RNA-Seq using Illumina HiSeq 2500®, and Affymetrix GeneChip® Mouse Transcriptome Array. Initial studies were performed using four male mouse brains (8 wk) that were pooled from different litters and cages of wild-type and MNX mice. Significant and selective differential DNA methylation and gene expression patterns were observed and indicate that there are some global, some subtle, but mostly reproducible, differences between these strains. Pathway analysis show clustering of changes involving cell adhesion, ion channels, cell surface receptors, metabolism and molecules involved in transport. Together these observations provide insights into how mtDNA could be altering epigenetic regulation and thereby contribute to cancer pathogenesis. Support: Susan G. Komen for the Cure (SAC11037), Natl Fndn Cancer Res, Steiner Family Fund for Metastasis Research, Kansas Bioscience Authority CA134981, P30-CA168524 Citation Format: Carolyn J. Vivian, Amanda E. Brinker, Gerald C. Gooden, Christophe Legendre, Samuel Turpin, Devin C. Koestler, Bodour Salhia, Danny R. Welch. Mitochondrial genomic backgrounds affect nuclear DNA methylation and gene expression. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2784." @default.
- W2488445062 created "2016-08-23" @default.
- W2488445062 creator A5037358272 @default.
- W2488445062 creator A5046887908 @default.
- W2488445062 creator A5050155323 @default.
- W2488445062 creator A5056217370 @default.
- W2488445062 creator A5076385474 @default.
- W2488445062 creator A5080153561 @default.
- W2488445062 creator A5085346929 @default.
- W2488445062 creator A5090609232 @default.
- W2488445062 date "2016-07-15" @default.
- W2488445062 modified "2023-10-10" @default.
- W2488445062 title "Abstract 2784: Mitochondrial genomic backgrounds affect nuclear DNA methylation and gene expression" @default.
- W2488445062 doi "https://doi.org/10.1158/1538-7445.am2016-2784" @default.
- W2488445062 hasPublicationYear "2016" @default.
- W2488445062 type Work @default.
- W2488445062 sameAs 2488445062 @default.
- W2488445062 citedByCount "0" @default.
- W2488445062 crossrefType "proceedings-article" @default.
- W2488445062 hasAuthorship W2488445062A5037358272 @default.
- W2488445062 hasAuthorship W2488445062A5046887908 @default.
- W2488445062 hasAuthorship W2488445062A5050155323 @default.
- W2488445062 hasAuthorship W2488445062A5056217370 @default.
- W2488445062 hasAuthorship W2488445062A5076385474 @default.
- W2488445062 hasAuthorship W2488445062A5080153561 @default.
- W2488445062 hasAuthorship W2488445062A5085346929 @default.
- W2488445062 hasAuthorship W2488445062A5090609232 @default.
- W2488445062 hasConcept C104317684 @default.
- W2488445062 hasConcept C115960442 @default.
- W2488445062 hasConcept C117717151 @default.
- W2488445062 hasConcept C150194340 @default.
- W2488445062 hasConcept C153911025 @default.
- W2488445062 hasConcept C162317418 @default.
- W2488445062 hasConcept C190727270 @default.
- W2488445062 hasConcept C20750100 @default.
- W2488445062 hasConcept C24586158 @default.
- W2488445062 hasConcept C41091548 @default.
- W2488445062 hasConcept C54355233 @default.
- W2488445062 hasConcept C86803240 @default.
- W2488445062 hasConceptScore W2488445062C104317684 @default.
- W2488445062 hasConceptScore W2488445062C115960442 @default.
- W2488445062 hasConceptScore W2488445062C117717151 @default.
- W2488445062 hasConceptScore W2488445062C150194340 @default.
- W2488445062 hasConceptScore W2488445062C153911025 @default.
- W2488445062 hasConceptScore W2488445062C162317418 @default.
- W2488445062 hasConceptScore W2488445062C190727270 @default.
- W2488445062 hasConceptScore W2488445062C20750100 @default.
- W2488445062 hasConceptScore W2488445062C24586158 @default.
- W2488445062 hasConceptScore W2488445062C41091548 @default.
- W2488445062 hasConceptScore W2488445062C54355233 @default.
- W2488445062 hasConceptScore W2488445062C86803240 @default.
- W2488445062 hasLocation W24884450621 @default.
- W2488445062 hasOpenAccess W2488445062 @default.
- W2488445062 hasPrimaryLocation W24884450621 @default.
- W2488445062 hasRelatedWork W1992438876 @default.
- W2488445062 hasRelatedWork W2059891246 @default.
- W2488445062 hasRelatedWork W2111413789 @default.
- W2488445062 hasRelatedWork W2120005496 @default.
- W2488445062 hasRelatedWork W2154716161 @default.
- W2488445062 hasRelatedWork W2155386974 @default.
- W2488445062 hasRelatedWork W2170205642 @default.
- W2488445062 hasRelatedWork W2355006125 @default.
- W2488445062 hasRelatedWork W2548744914 @default.
- W2488445062 hasRelatedWork W2614055979 @default.
- W2488445062 hasRelatedWork W2729586143 @default.
- W2488445062 hasRelatedWork W2756196902 @default.
- W2488445062 hasRelatedWork W2800720120 @default.
- W2488445062 hasRelatedWork W2891380603 @default.
- W2488445062 hasRelatedWork W2891817517 @default.
- W2488445062 hasRelatedWork W2905334696 @default.
- W2488445062 hasRelatedWork W2905337667 @default.
- W2488445062 hasRelatedWork W2976444553 @default.
- W2488445062 hasRelatedWork W3033320738 @default.
- W2488445062 hasRelatedWork W3126884424 @default.
- W2488445062 isParatext "false" @default.
- W2488445062 isRetracted "false" @default.
- W2488445062 magId "2488445062" @default.
- W2488445062 workType "article" @default.