FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2488468512> ?p ?o ?g. }

• W2488468512 endingPage "8340" @default.
• W2488468512 startingPage "8329" @default.
• W2488468512 abstract "The computational role of spike time synchronization at millisecond precision among neurons in the cerebral cortex is hotly debated. Studies performed on data of limited size provided experimental evidence that low-order correlations occur in relation to behavior. Advances in electrophysiological technology to record from hundreds of neurons simultaneously provide the opportunity to observe coordinated spiking activity of larger populations of cells. We recently published a method that combines data mining and statistical evaluation to search for significant patterns of synchronous spikes in massively parallel spike trains (Torre et al., 2013). The method solves the computational and multiple testing problems raised by the high dimensionality of the data. In the current study, we used our method on simultaneous recordings from two macaque monkeys engaged in an instructed-delay reach-to-grasp task to determine the emergence of spike synchronization in relation to behavior. We found a multitude of synchronous spike patterns aligned in both monkeys along a preferential mediolateral orientation in brain space. The occurrence of the patterns is highly specific to behavior, indicating that different behaviors are associated with the synchronization of different groups of neurons (“cell assemblies”). However, pooled patterns that overlap in neuronal composition exhibit no specificity, suggesting that exclusive cell assemblies become active during different behaviors, but can recruit partly identical neurons. These findings are consistent across multiple recording sessions analyzed across the two monkeys. <b>SIGNIFICANCE STATEMENT</b> Neurons in the brain communicate via electrical impulses called spikes. How spikes are coordinated to process information is still largely unknown. Synchronous spikes are effective in triggering a spike emission in receiving neurons and have been shown to occur in relation to behavior in a number of studies on simultaneous recordings of few neurons. We recently published a method to extend this type of investigation to larger data. Here, we apply it to simultaneous recordings of hundreds of neurons from the motor cortex of macaque monkeys performing a motor task. Our analysis reveals groups of neurons selectively synchronizing their activity in relation to behavior, which sheds new light on the role of synchrony in information processing in the cerebral cortex." @default.
• W2488468512 created "2016-08-23" @default.
• W2488468512 creator A5027290617 @default.
• W2488468512 creator A5048613858 @default.
• W2488468512 creator A5059503434 @default.
• W2488468512 creator A5072140128 @default.
• W2488468512 creator A5072220479 @default.
• W2488468512 creator A5078775405 @default.
• W2488468512 date "2016-08-10" @default.
• W2488468512 modified "2023-10-13" @default.
• W2488468512 title "Synchronous Spike Patterns in Macaque Motor Cortex during an Instructed-Delay Reach-to-Grasp Task" @default.
• W2488468512 cites W1483569340 @default.
• W2488468512 cites W1539683305 @default.
• W2488468512 cites W1973752972 @default.
• W2488468512 cites W1982570959 @default.
• W2488468512 cites W2001614757 @default.
• W2488468512 cites W2007495909 @default.
• W2488468512 cites W2018255768 @default.
• W2488468512 cites W2019849436 @default.
• W2488468512 cites W2024135393 @default.
• W2488468512 cites W2029602052 @default.
• W2488468512 cites W2038248646 @default.
• W2488468512 cites W2039105805 @default.
• W2488468512 cites W2049161026 @default.
• W2488468512 cites W2063528458 @default.
• W2488468512 cites W2069639055 @default.
• W2488468512 cites W2079757511 @default.
• W2488468512 cites W2079948225 @default.
• W2488468512 cites W2084793648 @default.
• W2488468512 cites W2085965317 @default.
• W2488468512 cites W2096233035 @default.
• W2488468512 cites W2099496298 @default.
• W2488468512 cites W2104251755 @default.
• W2488468512 cites W2105564023 @default.
• W2488468512 cites W2105608836 @default.
• W2488468512 cites W2110963038 @default.
• W2488468512 cites W2112002552 @default.
• W2488468512 cites W2116797486 @default.
• W2488468512 cites W2119417890 @default.
• W2488468512 cites W2128432504 @default.
• W2488468512 cites W2144146934 @default.
• W2488468512 cites W2151229057 @default.
• W2488468512 cites W2172294131 @default.
• W2488468512 cites W2240970145 @default.
• W2488468512 cites W2258755109 @default.
• W2488468512 cites W2335295386 @default.
• W2488468512 cites W2341008280 @default.
• W2488468512 doi "https://doi.org/10.1523/jneurosci.4375-15.2016" @default.
• W2488468512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4978798" @default.
• W2488468512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27511007" @default.
• W2488468512 hasPublicationYear "2016" @default.
• W2488468512 type Work @default.
• W2488468512 sameAs 2488468512 @default.
• W2488468512 citedByCount "38" @default.
• W2488468512 countsByYear W24884685122016 @default.
• W2488468512 countsByYear W24884685122017 @default.
• W2488468512 countsByYear W24884685122018 @default.
• W2488468512 countsByYear W24884685122019 @default.
• W2488468512 countsByYear W24884685122020 @default.
• W2488468512 countsByYear W24884685122021 @default.
• W2488468512 countsByYear W24884685122022 @default.
• W2488468512 countsByYear W24884685122023 @default.
• W2488468512 crossrefType "journal-article" @default.
• W2488468512 hasAuthorship W2488468512A5027290617 @default.
• W2488468512 hasAuthorship W2488468512A5048613858 @default.
• W2488468512 hasAuthorship W2488468512A5059503434 @default.
• W2488468512 hasAuthorship W2488468512A5072140128 @default.
• W2488468512 hasAuthorship W2488468512A5072220479 @default.
• W2488468512 hasAuthorship W2488468512A5078775405 @default.
• W2488468512 hasBestOaLocation W24884685121 @default.
• W2488468512 hasConcept C115903868 @default.
• W2488468512 hasConcept C127162648 @default.
• W2488468512 hasConcept C15744967 @default.
• W2488468512 hasConcept C162324750 @default.
• W2488468512 hasConcept C169760540 @default.
• W2488468512 hasConcept C185263204 @default.
• W2488468512 hasConcept C187736073 @default.
• W2488468512 hasConcept C2778562939 @default.
• W2488468512 hasConcept C2778950215 @default.
• W2488468512 hasConcept C2780451532 @default.
• W2488468512 hasConcept C2781390188 @default.
• W2488468512 hasConcept C31258907 @default.
• W2488468512 hasConcept C41008148 @default.
• W2488468512 hasConceptScore W2488468512C115903868 @default.
• W2488468512 hasConceptScore W2488468512C127162648 @default.
• W2488468512 hasConceptScore W2488468512C15744967 @default.
• W2488468512 hasConceptScore W2488468512C162324750 @default.
• W2488468512 hasConceptScore W2488468512C169760540 @default.
• W2488468512 hasConceptScore W2488468512C185263204 @default.
• W2488468512 hasConceptScore W2488468512C187736073 @default.
• W2488468512 hasConceptScore W2488468512C2778562939 @default.
• W2488468512 hasConceptScore W2488468512C2778950215 @default.
• W2488468512 hasConceptScore W2488468512C2780451532 @default.
• W2488468512 hasConceptScore W2488468512C2781390188 @default.
• W2488468512 hasConceptScore W2488468512C31258907 @default.
• W2488468512 hasConceptScore W2488468512C41008148 @default.
• W2488468512 hasIssue "32" @default.
• W2488468512 hasLocation W24884685121 @default.

• next