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- W2488471535 abstract "ABSTRACT Poly- N -acetylglucosamine (PNAG) is a major component of the Staphylococcus epidermidis biofilm extracellular matrix. However, it is not yet clear how this polysaccharide impacts the host immune response and infection-associated pathology. Faster neutrophil recruitment and bacterial clearance were observed in mice challenged intraperitoneally with S. epidermidis biofilm cells of the PNAG-producing 9142 strain than in mice similarly challenged with the isogenic PNAG-defective M10 mutant. Moreover, intraperitoneal priming with 9142 cells exacerbated liver inflammatory pathology induced by a subsequent intravenous S. epidermidis challenge, compared to priming with M10 cells. The 9142-primed mice had elevated splenic CD4 + T cells producing gamma interferon and interleukin-17A, indicating that PNAG promoted cell-mediated immunity. Curiously, despite having more marked liver tissue pathology, 9142-primed mice also had splenic T regulatory cells with greater suppressive activity than those of their M10-primed counterparts. By showing that PNAG production by S. epidermidis biofilm cells exacerbates host inflammatory pathology, these results together suggest that this polysaccharide contributes to the clinical features associated with biofilm-derived infections." @default.
- W2488471535 created "2016-08-23" @default.
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- W2488471535 date "2016-10-01" @default.
- W2488471535 modified "2023-10-17" @default.
- W2488471535 title "Poly- <i>N</i> -Acetylglucosamine Production by Staphylococcus epidermidis Cells Increases Their <i>In Vivo</i> Proinflammatory Effect" @default.
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- W2488471535 doi "https://doi.org/10.1128/iai.00290-16" @default.
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