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- W2488474419 abstract "This chapter presents a robust genetic system to identify and characterize endogenous and environmental components involved in dopamine neuron degeneration for the Caenorhabditis elegans (C. elegans) models of Parkinson's disease (PD). C. elegans is a powerful genetic model system for exploring the molecular mechanisms of neuronal function and disease. One of the most significant advantages of C. elegans is the ease of generating genetic knockdown or deletion mutants to identify gene function. C. elegans is sensitive to the mitochondria complex I inhibitor rotenone, the insecticide that has been weakly associated with the propensity to develop PD. It is found that of the genes identified to date that have been associated with PD, only α-synuclein does not have a clear ortholog in C. elegans. C. elegans overexpression of human α-synuclein may also increase overall fitness. It is suggested in vertebrates α-synuclein may also function as a chaperone and to protect against proapoptotic stimuli, and C. elegans could be a useful genetic model to begin to identify the molecular components involved in the α-synuclein neuroprotection." @default.
- W2488474419 created "2016-08-23" @default.
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- W2488474419 date "2008-01-01" @default.
- W2488474419 modified "2023-09-26" @default.
- W2488474419 title "Caenorhabditis Elegans Models of Parkinson's Disease" @default.
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- W2488474419 doi "https://doi.org/10.1016/b978-0-12-374028-1.00026-9" @default.
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