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• W2488482092 abstract "The invention of recombinant DNA technology and the ability to generate monoclonal antibodies have revolutionized both the pharmaceutical industry and the way we treat serious or life-threatening diseases. However, the full potential of recombinant DNA technology would not have been realized without the contribution of a multitude of incremental innovations in optimizing biopharmaceutical manufacturing, optimizing Biologics properties including safety, serum half-life, route of administration, and lowering the risk of immunogenicity. The sum total of these innovations has propelled the biopharmaceuticals market to grow to over $140 billion, and biopharmaceuticals in the recent past have been among the very few growth drivers in an otherwise stagnant market. The purpose of this chapter is to review milestones and innovations along the success path of mAbs and other Biologics, will critically challenge successes and setbacks and will consider whether the approval of around 40 mAbs against just over 30 antigen targets is a sign of success or of failure. Several hundred mAbs are currently in clinical development, highlighting that the full commercial potential of mAbs has not yet been fully exploited. The next wave of innovation on biopharmaceuticals will include miniaturized antibodies, novel binding scaffolds, bispecific antibodies, oral availability of Biologics, antibody-drug conjugates, permeation of the blood–brain barrier, and targeting of Biologics to the cytoplasm. Highlights of the process of innovation on these potential new treatment paradigms will be critically reviewed with regards to their contribution to the next wave of truly transformative medicines that will be required to keep biopharmaceuticals on the trajectory of being the growth drivers for the pharmaceutical industry." @default.
• W2488482092 created "2016-08-23" @default.
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• W2488482092 date "2016-01-15" @default.
• W2488482092 modified "2023-10-17" @default.
• W2488482092 title "Forty Years of Innovation in Biopharmaceuticals - Will the Next 40 Years Be as Revolutionary?" @default.
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• W2488482092 doi "https://doi.org/10.1002/9783527693405.ch12" @default.
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