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- W2488551595 abstract "Patients with high-risk myelodysplastic syndromes (MDS) face a poor prognosis with a median survival time of less than 12 months. The only curvative treatment known so far is allogeneic bone marrow transplantation which is available for younger patients with an HLA-matched sibling and hence for a minority of cases only. Acute myeloid leukemia (AML)-type combination chemotherapy can achieve complete remissions (CR) in the range of 15%–51%, however, remission duration is short (1, 2). Treatment failures are due to primary drug resistance and a high early death rate. The latter may be related to a longer duration of treatment-induced aplasia as compared to AML.KeywordsAcute Myeloid LeukemiaComplete Remission RateCytosine ArabinosideHigh Early Death RateHigh Complete Remission RateThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W2488551595 date "1997-01-01" @default.
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- W2488551595 title "Preliminary Results of a Placebo-Controlled, Double-Blind Trial Evaluating Sequential HD-AraC/Mitoxantrone Induction Chemotherapy with or Without Granulocyte-Macrophage Colony-Stimulating Factor in Patients with High-Risk Myelodysplastic Syndromes" @default.
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- W2488551595 doi "https://doi.org/10.1007/978-3-642-60377-8_141" @default.
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