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- W2488647673 abstract "Sickle-cell disease is an inherited disorder resulting from an abnormality in the structure of a protein in the red blood cell called hemoglobin. It represents a spectrum of disorders ranging from the full-blown form, sickle-cell anemia, to the carrier state called sickle-cell trait. Also included in this spectrum are several other variant hemoglobin disorders, which all have the sickle hemoglobin. Sickle-cell anemia is the prototype for most molecular diseases and was the first disease to have its cause isolated to a single molecular change in the human genetic structure. This single change is responsible for all of the dramatic physiological changes and clinical events that occur in this disease." @default.
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- W2488647673 date "1993-01-29" @default.
- W2488647673 modified "2023-09-24" @default.
- W2488647673 title "Sickle-Cell Anemia" @default.
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- W2488647673 doi "https://doi.org/10.1017/chol9780521332866.189" @default.
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