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- W2488665003 abstract "Summary. We examined the morphological changes in the choriocapillaris in myopic chick eyes, induced by unilateral eyelid suturing on the first day after hatching, in order to elucidate the causes of chorioretinal atrophy which often results in severe visual disturbance. Examination of vascular casts of the choriocapillaris with scan ning electron microscopy (SEM) showed that the choriocapillaris in contralateral control eyes maintains high vascular density as the animals age, whereas that in myopic eyes significantly decreased in density during the 2nd and 8th weeks after lid suture, with significant decreases in individual capillary width. When examined with transmission electron microscopy (TEM), capillary endothelial cells greatly reduced the number of fenestrations. Linear lesions, known as lacquer cracks, frequently occurred at the fundus in myopic eyes after the 8th week where the capillary network was broken off. With light microscopy (LM), layers of the retinal pigment epithelium and photoreceptor cells were attenuated with cellular degeneration and atrophy at the cracks. The abnormal increase in axial length and equatorial diameter continued until 8 weeks. We suggest that the changes in the choriocapillaris are caused by excessive tissue stretch due to rapid ocular enlargement. These changes, and the reduction of capillary blood flow reported by Shih et a!., are likely to underlie myopic chorioretinal atrophy." @default.
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- W2488665003 date "1998-01-01" @default.
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- W2488665003 title "Changes in the Morphology of Choriocapillaris on Experimental Chick Myopia" @default.
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