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• W2488670587 abstract "Three-dimensional (3D) biocomposites based on chitosan (CS) and clinoptilolite (CPL) were prepared by cryogelation and their potential application as drug carriers was investigated. Variation of CPL content from 0 to 33wt.% allowed the formation of biocomposites with heterogeneous morphologies consisting of randomly distributed pores. The further increase of CPL content led to ordered porous architectures where parallel pore channels were observed. The CPL content had a strong influence on water uptake, as well as on the cumulative release of diclofenac sodium (DS) and indomethacin (IDM). It was demonstrated that the drug delivery preferentially takes place in phosphate buffer saline (pH 7.4) in comparison to simulated gastric fluid (pH 1.2), where only a reduced drug release was observed. The drug release mechanism dominating these systems is described as a pseudo-Fickian diffusion, but it changes to non-Fickian release when 33wt.% of CPL was entrapped into the CS matrix or when IDM was loaded into biocomposites." @default.
• W2488670587 created "2016-08-23" @default.
• W2488670587 creator A5030834748 @default.
• W2488670587 creator A5049412645 @default.
• W2488670587 creator A5083108064 @default.
• W2488670587 date "2016-11-01" @default.
• W2488670587 modified "2023-09-25" @default.
• W2488670587 title "Synthesis, characterization and drug release properties of 3D chitosan/clinoptilolite biocomposite cryogels" @default.
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• W2488670587 doi "https://doi.org/10.1016/j.carbpol.2016.07.111" @default.
• W2488670587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27561488" @default.
• W2488670587 hasPublicationYear "2016" @default.
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