Matches in SemOpenAlex for { <https://semopenalex.org/work/W2488697908> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2488697908 endingPage "88" @default.
- W2488697908 startingPage "83" @default.
- W2488697908 abstract "Abstract The treatment of psychosis in patients with Parkinson's disease (PD) is one of the most difficult problems in clinical psychiatry. Clozapine's low propensity to induce extrapyramidal side effects makes it an attractive treatment for psychotic patients with PD. A number of published uncontrolled studies suggest that low-dose clozapine is effective in these patients. However, the dose range, side effect profiles and length of treatment have varied in these reports. In this article, the authors review the literature and report on the effects of clozapine in a patient with Parkinson's disease and psychosis. Clozapine (50mg per day) resulted in a complete resolution of psychosis, improvement of motor function, reduction of “off” time and a major improvement in levodopa-induced dystonic dyskinesias. The only adverse effect was mild sedation during the first two weeks of clozapine treatment. The lack of acute blockade of striatal D2 receptors by clozapine and the failure of chronic clozapine treatment to suppress striatal dopamine release may account for its beneficial effect in Parkinson's disease. Additionally, an ameliorating effect of clozapine on parkinsonism might be due to its action on serotonergic systems leading to release of striatal dopamine." @default.
- W2488697908 created "2016-08-23" @default.
- W2488697908 creator A5055216000 @default.
- W2488697908 creator A5059551708 @default.
- W2488697908 date "1994-06-01" @default.
- W2488697908 modified "2023-10-14" @default.
- W2488697908 title "Clozapine for the treatment of levodopa-induced psychosis and dyskinesia in Parkinson's disease" @default.
- W2488697908 cites W168421327 @default.
- W2488697908 cites W1973039143 @default.
- W2488697908 cites W1973761685 @default.
- W2488697908 cites W1983963467 @default.
- W2488697908 cites W1986353650 @default.
- W2488697908 cites W1994140491 @default.
- W2488697908 cites W1994959480 @default.
- W2488697908 cites W2000454212 @default.
- W2488697908 cites W2013295370 @default.
- W2488697908 cites W2025666055 @default.
- W2488697908 cites W2038190774 @default.
- W2488697908 cites W2039096389 @default.
- W2488697908 cites W2055083785 @default.
- W2488697908 cites W2055352169 @default.
- W2488697908 cites W2059230444 @default.
- W2488697908 cites W2062134604 @default.
- W2488697908 cites W2072069319 @default.
- W2488697908 cites W2072079883 @default.
- W2488697908 cites W2083837318 @default.
- W2488697908 cites W2094407307 @default.
- W2488697908 cites W2097393439 @default.
- W2488697908 cites W2160062235 @default.
- W2488697908 cites W2261695659 @default.
- W2488697908 cites W2314904848 @default.
- W2488697908 cites W2407633224 @default.
- W2488697908 cites W2412205566 @default.
- W2488697908 cites W2419057827 @default.
- W2488697908 doi "https://doi.org/10.1017/s0790966700012404" @default.
- W2488697908 hasPublicationYear "1994" @default.
- W2488697908 type Work @default.
- W2488697908 sameAs 2488697908 @default.
- W2488697908 citedByCount "1" @default.
- W2488697908 crossrefType "journal-article" @default.
- W2488697908 hasAuthorship W2488697908A5055216000 @default.
- W2488697908 hasAuthorship W2488697908A5059551708 @default.
- W2488697908 hasConcept C118552586 @default.
- W2488697908 hasConcept C126322002 @default.
- W2488697908 hasConcept C15744967 @default.
- W2488697908 hasConcept C197934379 @default.
- W2488697908 hasConcept C2776412080 @default.
- W2488697908 hasConcept C2776525014 @default.
- W2488697908 hasConcept C2776814716 @default.
- W2488697908 hasConcept C2779134260 @default.
- W2488697908 hasConcept C2779158372 @default.
- W2488697908 hasConcept C2779727114 @default.
- W2488697908 hasConcept C2779734285 @default.
- W2488697908 hasConcept C2780304432 @default.
- W2488697908 hasConcept C2780405171 @default.
- W2488697908 hasConcept C2780864610 @default.
- W2488697908 hasConcept C42219234 @default.
- W2488697908 hasConcept C513476851 @default.
- W2488697908 hasConcept C71924100 @default.
- W2488697908 hasConcept C98274493 @default.
- W2488697908 hasConceptScore W2488697908C118552586 @default.
- W2488697908 hasConceptScore W2488697908C126322002 @default.
- W2488697908 hasConceptScore W2488697908C15744967 @default.
- W2488697908 hasConceptScore W2488697908C197934379 @default.
- W2488697908 hasConceptScore W2488697908C2776412080 @default.
- W2488697908 hasConceptScore W2488697908C2776525014 @default.
- W2488697908 hasConceptScore W2488697908C2776814716 @default.
- W2488697908 hasConceptScore W2488697908C2779134260 @default.
- W2488697908 hasConceptScore W2488697908C2779158372 @default.
- W2488697908 hasConceptScore W2488697908C2779727114 @default.
- W2488697908 hasConceptScore W2488697908C2779734285 @default.
- W2488697908 hasConceptScore W2488697908C2780304432 @default.
- W2488697908 hasConceptScore W2488697908C2780405171 @default.
- W2488697908 hasConceptScore W2488697908C2780864610 @default.
- W2488697908 hasConceptScore W2488697908C42219234 @default.
- W2488697908 hasConceptScore W2488697908C513476851 @default.
- W2488697908 hasConceptScore W2488697908C71924100 @default.
- W2488697908 hasConceptScore W2488697908C98274493 @default.
- W2488697908 hasIssue "2" @default.
- W2488697908 hasLocation W24886979081 @default.
- W2488697908 hasOpenAccess W2488697908 @default.
- W2488697908 hasPrimaryLocation W24886979081 @default.
- W2488697908 hasRelatedWork W2017421211 @default.
- W2488697908 hasRelatedWork W2070662185 @default.
- W2488697908 hasRelatedWork W2086730902 @default.
- W2488697908 hasRelatedWork W2097393439 @default.
- W2488697908 hasRelatedWork W2488697908 @default.
- W2488697908 hasRelatedWork W2554582392 @default.
- W2488697908 hasRelatedWork W2588199757 @default.
- W2488697908 hasRelatedWork W2982184566 @default.
- W2488697908 hasRelatedWork W4254300694 @default.
- W2488697908 hasRelatedWork W794920924 @default.
- W2488697908 hasVolume "11" @default.
- W2488697908 isParatext "false" @default.
- W2488697908 isRetracted "false" @default.
- W2488697908 magId "2488697908" @default.
- W2488697908 workType "article" @default.