Matches in SemOpenAlex for { <https://semopenalex.org/work/W2488761434> ?p ?o ?g. }
- W2488761434 endingPage "420" @default.
- W2488761434 startingPage "393" @default.
- W2488761434 abstract "Publisher Summary Gene therapy technologies have advanced rapidly. Phase I and Phase II gene-based clinical trials are moving forward for the treatment of a variety of human diseases. The eye is well suited to gene therapy approaches, and significant advances have been made in developing gene therapy for certain ocular diseases. This chapter discusses various gene delivery methods. Once the strategy, the target cell/tissue and the target or therapeutic gene are determined, the most suitable method for efficiently delivering the gene to the cells must be chosen. The method selected must allow the gene to be expressed at an appropriate level, for a sufficient duration to achieve the desired therapeutic effects. In general, the mammalian cell membrane is impermeable to large electrically charged molecules, such as DNA, and presents a major barrier to the intracellular delivery of genes. A variety of methods have been tried to make the cells temporarily permeable to DNA or RNA, or to convey the genes into the cells. These methods can be roughly divided into two gene transfer approaches, viral or non-viral, and each approach has different advantages and disadvantages, regarding gene transfer efficiency and safety." @default.
- W2488761434 created "2016-08-23" @default.
- W2488761434 creator A5012234902 @default.
- W2488761434 creator A5031762920 @default.
- W2488761434 creator A5051555445 @default.
- W2488761434 creator A5053051072 @default.
- W2488761434 creator A5056637572 @default.
- W2488761434 creator A5082646052 @default.
- W2488761434 date "2008-01-01" @default.
- W2488761434 modified "2023-10-14" @default.
- W2488761434 title "Progress and Prospects in Ocular Gene Therapy" @default.
- W2488761434 cites W1004284833 @default.
- W2488761434 cites W1161068701 @default.
- W2488761434 cites W1163323894 @default.
- W2488761434 cites W1180058565 @default.
- W2488761434 cites W125668925 @default.
- W2488761434 cites W143018669 @default.
- W2488761434 cites W1477736510 @default.
- W2488761434 cites W1490065438 @default.
- W2488761434 cites W1491691148 @default.
- W2488761434 cites W1491764882 @default.
- W2488761434 cites W1497273958 @default.
- W2488761434 cites W1503493336 @default.
- W2488761434 cites W1510403526 @default.
- W2488761434 cites W1518328551 @default.
- W2488761434 cites W1526763790 @default.
- W2488761434 cites W1529146532 @default.
- W2488761434 cites W1551787508 @default.
- W2488761434 cites W1574320587 @default.
- W2488761434 cites W1584060797 @default.
- W2488761434 cites W1588415812 @default.
- W2488761434 cites W1597552483 @default.
- W2488761434 cites W1598779357 @default.
- W2488761434 cites W1604017947 @default.
- W2488761434 cites W1607032816 @default.
- W2488761434 cites W1608827381 @default.
- W2488761434 cites W177389335 @default.
- W2488761434 cites W17829668 @default.
- W2488761434 cites W1833357512 @default.
- W2488761434 cites W1868514048 @default.
- W2488761434 cites W1880142700 @default.
- W2488761434 cites W1918313756 @default.
- W2488761434 cites W1964502095 @default.
- W2488761434 cites W1966712770 @default.
- W2488761434 cites W1967004211 @default.
- W2488761434 cites W1968800607 @default.
- W2488761434 cites W1970895236 @default.
- W2488761434 cites W1971409321 @default.
- W2488761434 cites W1973389197 @default.
- W2488761434 cites W1974074261 @default.
- W2488761434 cites W1975655523 @default.
- W2488761434 cites W1976483918 @default.
- W2488761434 cites W1976755778 @default.
- W2488761434 cites W1978579854 @default.
- W2488761434 cites W1979244676 @default.
- W2488761434 cites W1979836825 @default.
- W2488761434 cites W1980448847 @default.
- W2488761434 cites W1984764475 @default.
- W2488761434 cites W1987434164 @default.
- W2488761434 cites W1989386072 @default.
- W2488761434 cites W1989430855 @default.
- W2488761434 cites W1991157268 @default.
- W2488761434 cites W1992009563 @default.
- W2488761434 cites W1995284319 @default.
- W2488761434 cites W1996008470 @default.
- W2488761434 cites W1996824302 @default.
- W2488761434 cites W1996875707 @default.
- W2488761434 cites W1999590560 @default.
- W2488761434 cites W2000188822 @default.
- W2488761434 cites W2000341011 @default.
- W2488761434 cites W2000676103 @default.
- W2488761434 cites W2001032066 @default.
- W2488761434 cites W2003244847 @default.
- W2488761434 cites W2004358897 @default.
- W2488761434 cites W2004388484 @default.
- W2488761434 cites W2004983645 @default.
- W2488761434 cites W2005088734 @default.
- W2488761434 cites W2008070617 @default.
- W2488761434 cites W2008286480 @default.
- W2488761434 cites W2008512248 @default.
- W2488761434 cites W2008688504 @default.
- W2488761434 cites W2012088978 @default.
- W2488761434 cites W2013163435 @default.
- W2488761434 cites W2013453300 @default.
- W2488761434 cites W2015879357 @default.
- W2488761434 cites W2019950862 @default.
- W2488761434 cites W2020149574 @default.
- W2488761434 cites W2020308246 @default.
- W2488761434 cites W2021846751 @default.
- W2488761434 cites W2022084143 @default.
- W2488761434 cites W2026857465 @default.
- W2488761434 cites W2028291183 @default.
- W2488761434 cites W2029389016 @default.
- W2488761434 cites W2031912773 @default.
- W2488761434 cites W2032114130 @default.
- W2488761434 cites W2032379708 @default.
- W2488761434 cites W2033377653 @default.
- W2488761434 cites W2033828028 @default.