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- W2488778947 abstract "Novel giant and flexible worm micelles were self-assembled from degradable copolymer poly (ethylene oxide)-block-polycaprolactone (OCL). Such worm micelles spontaneously shorten to spherical micelles, triggered by hydrolytic degradation of polycaprolactone. Unique degradation mechanism and kinetics in OCL worm micelles were elucidated, and key activating conditions of temperature, pH, and polymer molecular weight were quantitatively assessed. We have also demonstrated that degradable OCL worm micelles possess great potenial as novel controlled-release drug delivery vehicle: they are compatible with cultured cells and blood, capable of loading a model hydrophobic anticancer drug (taxol), easy storage, and the release of the drug is controlled by OCL worm micelle degradation rate." @default.
- W2488778947 created "2016-08-23" @default.
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- W2488778947 date "2006-09-23" @default.
- W2488778947 modified "2023-10-16" @default.
- W2488778947 title "Degradable Poly(ethylene oxide)-<i>block</i>-Polycaprolactone Worm Micelles" @default.
- W2488778947 doi "https://doi.org/10.1021/bk-2006-0939.ch011" @default.
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