Matches in SemOpenAlex for { <https://semopenalex.org/work/W2488782322> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2488782322 abstract "Hydroxytyrosol (OHTYR) is a phenolic compound with antioxidant activity present in olive oil and wine. After ingestion, it undergoes extensive phase II metabolism giving rise to different sulphate and glucuronide conjugates to the extent that the free form is deemed undetectable in plasma. We have developed two different methods to quantify separately: (i) free OHTYR and (ii) OHTYR metabolites in human plasma by LC/MS/MS. Because low concentrations, free OHTYR determination includes a benzylamine derivatization in order to increase sensitivity (LOD=0.3 ng/mL, LLOQ=1 ng/mL)1. The methods have been applied to monitor the circulating levels of free OHTYR and its metabolites following the ingestion of extra-virgin olive oil (45 mL). OHTYR was rapidly absorbed (Tmax = 30 – 45 minutes) and metabolized. According to AUCs, OHTYR was mainly found in plasma in the form of sulphates (53%) and glucuronides (42%) whereas free OHTYR accounted for less than 5%. Because of the low bioavailability of the free form of OHTYR, the biological activity of metabolites should be investigated more in depth. Analytical methods reported are a valuable tool to better understand health benefits derived from the ingestion of foods containing OHTYR." @default.
- W2488782322 created "2016-08-23" @default.
- W2488782322 creator A5010113440 @default.
- W2488782322 creator A5019025652 @default.
- W2488782322 creator A5020006084 @default.
- W2488782322 creator A5035424924 @default.
- W2488782322 creator A5053016661 @default.
- W2488782322 creator A5083373223 @default.
- W2488782322 date "2016-03-07" @default.
- W2488782322 modified "2023-09-26" @default.
- W2488782322 title "DETERMINATION OF FREE AND CONJUGATED HYDROXYTYROSOL IN HUMAN PLASMA FOLLOWING OLIVE OIL ADMINISTRATION" @default.
- W2488782322 doi "https://doi.org/10.18143/jisanh_v3i4_1279" @default.
- W2488782322 hasPublicationYear "2016" @default.
- W2488782322 type Work @default.
- W2488782322 sameAs 2488782322 @default.
- W2488782322 citedByCount "0" @default.
- W2488782322 crossrefType "journal-article" @default.
- W2488782322 hasAuthorship W2488782322A5010113440 @default.
- W2488782322 hasAuthorship W2488782322A5019025652 @default.
- W2488782322 hasAuthorship W2488782322A5020006084 @default.
- W2488782322 hasAuthorship W2488782322A5035424924 @default.
- W2488782322 hasAuthorship W2488782322A5053016661 @default.
- W2488782322 hasAuthorship W2488782322A5083373223 @default.
- W2488782322 hasConcept C179998833 @default.
- W2488782322 hasConcept C181389837 @default.
- W2488782322 hasConcept C185592680 @default.
- W2488782322 hasConcept C193230392 @default.
- W2488782322 hasConcept C2775881703 @default.
- W2488782322 hasConcept C2776923573 @default.
- W2488782322 hasConcept C2777056448 @default.
- W2488782322 hasConcept C2778004101 @default.
- W2488782322 hasConcept C2779186261 @default.
- W2488782322 hasConcept C2781397249 @default.
- W2488782322 hasConcept C2988377048 @default.
- W2488782322 hasConcept C31903555 @default.
- W2488782322 hasConcept C43617362 @default.
- W2488782322 hasConcept C55493867 @default.
- W2488782322 hasConcept C62231903 @default.
- W2488782322 hasConcept C70899900 @default.
- W2488782322 hasConcept C86803240 @default.
- W2488782322 hasConcept C98274493 @default.
- W2488782322 hasConceptScore W2488782322C179998833 @default.
- W2488782322 hasConceptScore W2488782322C181389837 @default.
- W2488782322 hasConceptScore W2488782322C185592680 @default.
- W2488782322 hasConceptScore W2488782322C193230392 @default.
- W2488782322 hasConceptScore W2488782322C2775881703 @default.
- W2488782322 hasConceptScore W2488782322C2776923573 @default.
- W2488782322 hasConceptScore W2488782322C2777056448 @default.
- W2488782322 hasConceptScore W2488782322C2778004101 @default.
- W2488782322 hasConceptScore W2488782322C2779186261 @default.
- W2488782322 hasConceptScore W2488782322C2781397249 @default.
- W2488782322 hasConceptScore W2488782322C2988377048 @default.
- W2488782322 hasConceptScore W2488782322C31903555 @default.
- W2488782322 hasConceptScore W2488782322C43617362 @default.
- W2488782322 hasConceptScore W2488782322C55493867 @default.
- W2488782322 hasConceptScore W2488782322C62231903 @default.
- W2488782322 hasConceptScore W2488782322C70899900 @default.
- W2488782322 hasConceptScore W2488782322C86803240 @default.
- W2488782322 hasConceptScore W2488782322C98274493 @default.
- W2488782322 hasIssue "4" @default.
- W2488782322 hasLocation W24887823221 @default.
- W2488782322 hasOpenAccess W2488782322 @default.
- W2488782322 hasPrimaryLocation W24887823221 @default.
- W2488782322 hasRelatedWork W1967319145 @default.
- W2488782322 hasRelatedWork W1975910971 @default.
- W2488782322 hasRelatedWork W2012317379 @default.
- W2488782322 hasRelatedWork W2030229158 @default.
- W2488782322 hasRelatedWork W2080450550 @default.
- W2488782322 hasRelatedWork W2081369896 @default.
- W2488782322 hasRelatedWork W2084023771 @default.
- W2488782322 hasRelatedWork W2091270126 @default.
- W2488782322 hasRelatedWork W2094803907 @default.
- W2488782322 hasRelatedWork W2160293048 @default.
- W2488782322 hasRelatedWork W2183559003 @default.
- W2488782322 hasRelatedWork W2286204632 @default.
- W2488782322 hasRelatedWork W2315155772 @default.
- W2488782322 hasRelatedWork W2415946273 @default.
- W2488782322 hasRelatedWork W2762744325 @default.
- W2488782322 hasRelatedWork W2767269642 @default.
- W2488782322 hasRelatedWork W2983835694 @default.
- W2488782322 hasRelatedWork W3157092249 @default.
- W2488782322 hasRelatedWork W2184053108 @default.
- W2488782322 hasRelatedWork W2498776020 @default.
- W2488782322 hasVolume "3" @default.
- W2488782322 isParatext "false" @default.
- W2488782322 isRetracted "false" @default.
- W2488782322 magId "2488782322" @default.
- W2488782322 workType "article" @default.