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- W2488783752 abstract "The development of reliable techniques for transformation of plant cells has led to the possibility of expressing a range of proteins in plants. Of these, expression of antibodies is perhaps the most interesting, because there are so many potential applications. Plants could be used as bio-reactors for large scale antibody production, alternatively, antibodies could be used to modulate plant biochemistry, or influence disease resistance. Antibody processing in plants is very similar to that found in mammalian plasma cells. Signal sequences direct the light and heavy chains to the endoplasmic reticulum for assembly and glycosylation and the assembled antibody is secreted, via the Golgi apparatus. The potential for antibody engineering in plants is high. Modifications to the heavy chain, including the extension of the heavy chain by one domain, can be accomodated without affecting the fidelity of assembly. Antibody fragments can also be produced which may be targeted for secretion, or for intracellular expression by removal of the signal sequence. Secreted antibody accumulates in the extracellular apoplastic fluid, which is a vast, but stable environment, and so levels of recovery can be extremely high." @default.
- W2488783752 created "2016-08-23" @default.
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- W2488783752 date "1995-08-18" @default.
- W2488783752 modified "2023-09-24" @default.
- W2488783752 title "Antibody Expression in Plants" @default.
- W2488783752 doi "https://doi.org/10.1021/bk-1995-0604.ch005" @default.
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