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• W2488808215 endingPage "1229" @default.
• W2488808215 startingPage "1211" @default.
• W2488808215 abstract "Thirty years after the identification of the human immunodeficiency virus (HIV) as the etiologic agent for AIDS, there are still no effective vaccines and no sterilizing cures. Fortunately, combination antiretroviral therapy (cART) has turned a deadly disease into a manageable, chronic condition. Effective and lifelong antiretroviral therapy is the foundation of the fight to reduce HIV-associated morbidity and mortality, and to improve the quality of life for the estimated 33.3 million persons living with HIV. Antiretroviral treatment, however, is associated with a number of toxicities that range from mild to life-threatening and that affect nearly all organ systems. As the number of people on cART increases and the population ages, genetic predictors of toxicities and age-related morbidities due to cART become increasingly critical. There has been intensive genetic investigation in an effort to explain the variability in HIV/AIDS, to identify potential targets for therapeutic intervention, and to reveal the genetic basis for interpersonal and interpopulation variation in efficacy and toxicities associated with antiretroviral therapies [An, P. and Winkler, C.A. (2010) Trends Genet 26, 119–131; Aouizerat, B.E., Pearce, C.L. and Miaskowski, C. (2011) Curr HIV/AIDS Rep 8, 38–44; Tozzi, V. (2010) Antiviral Res 85, 190–200]. These studies have identified a number of genetic variants that are important correlates of HIV pathogenesis and antiretroviral therapy. Whole-genome association studies in the general population have revealed genetic factors associated with metabolic disorders (i.e., type 2 diabetes mellitus and lipodystrophy); genetic profiling might have utility in the choice of cART regimens to avoid drugs associated with metabolic toxicities. Pharmacogenetics is just beginning to be incorporated into clinical practice, most notably screening for HLA-B*5701 , which is associated with abacavir hypersensitivity reaction. Here we review the role of pharmacogenetics and pharmacogenomics in HIV therapy and drug-related toxicities, the utility of genetic screening for personalized HIV care, and what is needed to bring personalized, genetics-informed care to the clinic." @default.
• W2488808215 created "2016-08-23" @default.
• W2488808215 creator A5024733766 @default.
• W2488808215 creator A5081712694 @default.
• W2488808215 creator A5082182356 @default.
• W2488808215 date "2013-01-01" @default.
• W2488808215 modified "2023-09-25" @default.
• W2488808215 title "HIV Pharmacogenetics and Pharmacogenomics" @default.
• W2488808215 cites W114558098 @default.
• W2488808215 cites W119112029 @default.
• W2488808215 cites W1498945648 @default.
• W2488808215 cites W173494530 @default.
• W2488808215 cites W1767400858 @default.
• W2488808215 cites W1904151121 @default.
• W2488808215 cites W1968439455 @default.
• W2488808215 cites W1970794988 @default.
• W2488808215 cites W1972194246 @default.
• W2488808215 cites W1972242699 @default.
• W2488808215 cites W1975960962 @default.
• W2488808215 cites W1980162669 @default.
• W2488808215 cites W1980991473 @default.
• W2488808215 cites W1981710814 @default.
• W2488808215 cites W1983720602 @default.
• W2488808215 cites W1986250953 @default.
• W2488808215 cites W1986541127 @default.
• W2488808215 cites W1988226703 @default.
• W2488808215 cites W1988633607 @default.
• W2488808215 cites W1988812212 @default.
• W2488808215 cites W1991088839 @default.
• W2488808215 cites W1994872511 @default.
• W2488808215 cites W1996083965 @default.
• W2488808215 cites W1996389250 @default.
• W2488808215 cites W1996472402 @default.
• W2488808215 cites W1997824449 @default.
• W2488808215 cites W1998717100 @default.
• W2488808215 cites W1999540072 @default.
• W2488808215 cites W2001169776 @default.
• W2488808215 cites W2001316390 @default.
• W2488808215 cites W2001435229 @default.
• W2488808215 cites W2003529614 @default.
• W2488808215 cites W2005270107 @default.
• W2488808215 cites W2006240275 @default.
• W2488808215 cites W2007142745 @default.
• W2488808215 cites W2009516154 @default.
• W2488808215 cites W2011912864 @default.
• W2488808215 cites W2014863810 @default.
• W2488808215 cites W2017793579 @default.
• W2488808215 cites W2020617004 @default.
• W2488808215 cites W2021318193 @default.
• W2488808215 cites W2022552811 @default.
• W2488808215 cites W2026191990 @default.
• W2488808215 cites W2026666645 @default.
• W2488808215 cites W2027918366 @default.
• W2488808215 cites W2032039529 @default.
• W2488808215 cites W2032074457 @default.
• W2488808215 cites W2035212948 @default.
• W2488808215 cites W2035312251 @default.
• W2488808215 cites W2035476310 @default.
• W2488808215 cites W2036030829 @default.
• W2488808215 cites W2039032252 @default.
• W2488808215 cites W2043249617 @default.
• W2488808215 cites W2044136054 @default.
• W2488808215 cites W2045229224 @default.
• W2488808215 cites W2049280919 @default.
• W2488808215 cites W2049501844 @default.
• W2488808215 cites W2049761843 @default.
• W2488808215 cites W2050617356 @default.
• W2488808215 cites W2051727386 @default.
• W2488808215 cites W2051736603 @default.
• W2488808215 cites W2051793219 @default.
• W2488808215 cites W2053382469 @default.
• W2488808215 cites W2053896303 @default.
• W2488808215 cites W2055713344 @default.
• W2488808215 cites W2055940153 @default.
• W2488808215 cites W2060210361 @default.
• W2488808215 cites W2061090904 @default.
• W2488808215 cites W2065543285 @default.
• W2488808215 cites W2066614023 @default.
• W2488808215 cites W2070676224 @default.
• W2488808215 cites W2072399876 @default.
• W2488808215 cites W2076105757 @default.
• W2488808215 cites W2079905097 @default.
• W2488808215 cites W2081661453 @default.
• W2488808215 cites W2081752205 @default.
• W2488808215 cites W2082126453 @default.
• W2488808215 cites W2086031035 @default.
• W2488808215 cites W2089378839 @default.
• W2488808215 cites W2091863056 @default.
• W2488808215 cites W2095442537 @default.
• W2488808215 cites W2096640504 @default.
• W2488808215 cites W2098800451 @default.
• W2488808215 cites W2098938825 @default.
• W2488808215 cites W2099354741 @default.
• W2488808215 cites W2101501447 @default.
• W2488808215 cites W2101761365 @default.
• W2488808215 cites W2102316672 @default.
• W2488808215 cites W2102661607 @default.
• W2488808215 cites W2102679591 @default.

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