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- W2488886536 abstract "This discrepancy raises the following questions: which estimate is correct’’; what is the reason for the disparity; and can the SDD model explain Bcd gradient formation within the experimentally observed times? In this paper, we use a simple biophysical model in which Bcd diffuses and interacts with binding sites to show that both the FRAP and the FCS estimates may be correct and compatible with the observed timescale of gradient formation. The discrepancy arises from the fact that FCS and FRAP report on different effective (concentration dependent) diffusion coefficients, one of which describes the spreading rate of the individual Bcd molecules (the messengers) and the other one that of their concentration (the message). The latter is the one that is more relevant for the gradient establishment and is compatible with its formation within the experimentally observed times." @default.
- W2488886536 created "2016-08-23" @default.
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- W2488886536 date "2015-12-03" @default.
- W2488886536 modified "2023-10-18" @default.
- W2488886536 title "Messages Diffuse Faster than Messengers Pitfalls in the Interpretation of Labeled Particle Motion" @default.
- W2488886536 doi "https://doi.org/10.2172/1228069" @default.
- W2488886536 hasPublicationYear "2015" @default.
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