Matches in SemOpenAlex for { <https://semopenalex.org/work/W2488941343> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2488941343 endingPage "26" @default.
- W2488941343 startingPage "22" @default.
- W2488941343 abstract "Chagas disease (CD) remains a major cause of cardiomyopathy and stroke in developing countries. Brain damage in CD has been attributed exclusively to the effects of structural heart disease on the brain, including cardioembolism and low cardiac output symptoms. However, CD patients also develop stroke and brain atrophy independently of cardiac disease severity. Chronic inflammation directed against T. cruzi may act as a trigger for endothelial damage, platelet activation, acceleration of atherosclerosis and apoptosis, all of which lead to stroke and brain atrophy. In the present article, evidence supporting this new theory is presented, along with considerations towards mechanistically-based targeted treatment.A doença de Chagas (DC) permanence uma causa importante de cardiomiopatia e acidente vascular cerebral em países em desenvolvimento. A lesão cerebral na DC tem sido atribuída aos efeitos da doença cardíaca estrutural no cérebro, incluindo cardioembolia e sintomas de baixo débito cardíaco. No entanto, pacientes com DC desenvolvem acidente vascular cerebral e atrofia cerebral independentemente da gravidade da cardiomiopatia. Inflamação crônica direcionada contra o T. cruzi pode agir como desencadeante de lesão endotelial, ativação plaquetária, aceleração de aterosclerose e apoptose, todos predispondo a acidente vascular cerebral e atrofia cerebral. Nesse artigo, as evidências que dão suporte a esta nova teoria são apresentadas, juntamente com argumentos direcionados a um tratamento baseado no mecanismo do dano cerebral." @default.
- W2488941343 created "2016-08-23" @default.
- W2488941343 creator A5085210882 @default.
- W2488941343 date "2009-03-01" @default.
- W2488941343 modified "2023-10-14" @default.
- W2488941343 title "Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition" @default.
- W2488941343 cites W1918619112 @default.
- W2488941343 cites W1972209585 @default.
- W2488941343 cites W1980820801 @default.
- W2488941343 cites W2001846443 @default.
- W2488941343 cites W2024434326 @default.
- W2488941343 cites W2032126029 @default.
- W2488941343 cites W2039182387 @default.
- W2488941343 cites W2044124550 @default.
- W2488941343 cites W2050814239 @default.
- W2488941343 cites W2056591660 @default.
- W2488941343 cites W2057815635 @default.
- W2488941343 cites W2075024860 @default.
- W2488941343 cites W2075936679 @default.
- W2488941343 cites W2077823972 @default.
- W2488941343 cites W2086680281 @default.
- W2488941343 cites W2093624321 @default.
- W2488941343 cites W2097839720 @default.
- W2488941343 cites W2103853204 @default.
- W2488941343 cites W2110320988 @default.
- W2488941343 cites W2131881334 @default.
- W2488941343 cites W2134072362 @default.
- W2488941343 cites W2146544216 @default.
- W2488941343 cites W2148104977 @default.
- W2488941343 cites W2149262891 @default.
- W2488941343 cites W2151848444 @default.
- W2488941343 cites W2169381152 @default.
- W2488941343 cites W2414968029 @default.
- W2488941343 cites W2415434971 @default.
- W2488941343 cites W4290259078 @default.
- W2488941343 doi "https://doi.org/10.1590/s1980-57642009dn30100005" @default.
- W2488941343 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5619027" @default.
- W2488941343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29213605" @default.
- W2488941343 hasPublicationYear "2009" @default.
- W2488941343 type Work @default.
- W2488941343 sameAs 2488941343 @default.
- W2488941343 citedByCount "10" @default.
- W2488941343 countsByYear W24889413432012 @default.
- W2488941343 countsByYear W24889413432013 @default.
- W2488941343 countsByYear W24889413432021 @default.
- W2488941343 countsByYear W24889413432023 @default.
- W2488941343 crossrefType "journal-article" @default.
- W2488941343 hasAuthorship W2488941343A5085210882 @default.
- W2488941343 hasBestOaLocation W24889413431 @default.
- W2488941343 hasConcept C112418997 @default.
- W2488941343 hasConcept C121332964 @default.
- W2488941343 hasConcept C126322002 @default.
- W2488941343 hasConcept C142724271 @default.
- W2488941343 hasConcept C164705383 @default.
- W2488941343 hasConcept C2778198053 @default.
- W2488941343 hasConcept C2778797674 @default.
- W2488941343 hasConcept C2780645631 @default.
- W2488941343 hasConcept C2781172350 @default.
- W2488941343 hasConcept C71924100 @default.
- W2488941343 hasConcept C97355855 @default.
- W2488941343 hasConceptScore W2488941343C112418997 @default.
- W2488941343 hasConceptScore W2488941343C121332964 @default.
- W2488941343 hasConceptScore W2488941343C126322002 @default.
- W2488941343 hasConceptScore W2488941343C142724271 @default.
- W2488941343 hasConceptScore W2488941343C164705383 @default.
- W2488941343 hasConceptScore W2488941343C2778198053 @default.
- W2488941343 hasConceptScore W2488941343C2778797674 @default.
- W2488941343 hasConceptScore W2488941343C2780645631 @default.
- W2488941343 hasConceptScore W2488941343C2781172350 @default.
- W2488941343 hasConceptScore W2488941343C71924100 @default.
- W2488941343 hasConceptScore W2488941343C97355855 @default.
- W2488941343 hasIssue "1" @default.
- W2488941343 hasLocation W24889413431 @default.
- W2488941343 hasLocation W24889413432 @default.
- W2488941343 hasLocation W24889413433 @default.
- W2488941343 hasLocation W24889413434 @default.
- W2488941343 hasLocation W24889413435 @default.
- W2488941343 hasOpenAccess W2488941343 @default.
- W2488941343 hasPrimaryLocation W24889413431 @default.
- W2488941343 hasRelatedWork W2002495768 @default.
- W2488941343 hasRelatedWork W2324190737 @default.
- W2488941343 hasRelatedWork W2342283418 @default.
- W2488941343 hasRelatedWork W2509135353 @default.
- W2488941343 hasRelatedWork W2598556589 @default.
- W2488941343 hasRelatedWork W2790155717 @default.
- W2488941343 hasRelatedWork W2790999183 @default.
- W2488941343 hasRelatedWork W3017174451 @default.
- W2488941343 hasRelatedWork W3156759488 @default.
- W2488941343 hasRelatedWork W4376279867 @default.
- W2488941343 hasVolume "3" @default.
- W2488941343 isParatext "false" @default.
- W2488941343 isRetracted "false" @default.
- W2488941343 magId "2488941343" @default.
- W2488941343 workType "article" @default.