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- W2488994498 abstract "Therapeutic efficacy and safety of pharmaceuticals remain a critical issue for successful NASA medical operations of long-term space missions on International Space Station (ISS). Medications stored aboard the ISS are subjected to unique environmental factors for extended time periods that may cause physicochemical degradation or alterations in the integrity of formulations that include the active pharmaceutical ingredient (API) and the chemical matrix of the formulation. Degradation of API and adjuvants, in addition to alterations of the chemical matrix of the formulation, can decrease potency and bioavailability and increase the risk due to toxicity of degraded medications. UPLC-MS/MS analysis is efficient and highly sensitive to quantify API content and MS analysis enables the elucidation of the structures of degradation products for each formulation. Therefore the aim of this project was to develop and validate a rapid, specific, and sensitive UPLC-MS/MS assay for the simultaneous determination of ibuprofen and promethazine in tablets stored aboard the ISS." @default.
- W2488994498 created "2016-08-23" @default.
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- W2488994498 date "2016-11-01" @default.
- W2488994498 modified "2023-09-26" @default.
- W2488994498 title "Development and Validation of an UPLC-MS/MS Method for Simultaneous Determination of Ibuprofen and Promethazine in Tablets Stored on Board the International Space Station" @default.
- W2488994498 doi "https://doi.org/10.26226/morressier.57d6b2bad462b8028d88e63b" @default.
- W2488994498 hasPublicationYear "2016" @default.
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