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• W2489029264 abstract "The quantification of neurofibrillary tangles (NFTs) using specific PET tracers can facilitate the diagnosis of Alzheimer’s disease (AD) and allow monitoring of disease progression and treatment efficacy. [18F]-THK523 has shown high affinity and selectivity for tau pathology. However, its high retention in white matter, which makes simple visual inspection difficult, may limit its use in research or clinical settings. In this paper, we optimized the automated radiosynthesis of [11C]-TKF and evaluated its biodistribution and toxicity in C57 mice. [11C]-TKF can be made by reaction precursor with [11C]MeOTf or 11CH3I, but [11C]MeOTf will give us higher labeling yields and specific activity. [11C]-TKF presented better brain uptake in normal mouse than [18F]-THK523 (3.23% ± 1.25% ID·g−1 vs. 2.62% ± 0.39% ID·g−1 at 2 min post-injection). The acute toxicity studies of [11C]-TKF were unremarkable." @default.
• W2489029264 created "2016-08-23" @default.
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• W2489029264 date "2016-08-05" @default.
• W2489029264 modified "2023-09-28" @default.
• W2489029264 title "Optimization and Biodistribution of [11C]-TKF, An Analog of Tau Protein Imaging Agent [18F]-THK523" @default.
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• W2489029264 doi "https://doi.org/10.3390/molecules21081019" @default.
• W2489029264 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6273120" @default.
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