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• W2489071766 abstract "The usage of biomarkers reflecting atherosclerosis progression is important for preventing serious incidence of cardiovascular events. To elucidate clinically relevant molecular determinants in atherosclerosis, we have taken a comprehensive approach to combine mass spectrometry-based differential proteomics using both clinical and animal model specimens. Clinical plasma samples were collected from patients with acute myocardial infarction (AMI), stable angina (SA), and healthy/low-risk individuals (H-LR). We also obtained plasma and arterial tissue samples from apolipoprotein E-deficient and wild-type mice at various pathognomonic points of age. Cleavable isotope-coded affinity tags were used for differential mass spectrometry. Differential proteomics of clinical plasma samples revealed that more than 10 proteins appeared to be upregulated (relative abundance AMI/H-LR or SA/H-LR >1.5) and 5 proteins downregulated (AMI/H-LR or SA/H-LR <1/1.5). These trends associated with the disease progression are not always coincident with those of mouse ortholog proteins, suggesting a pathophysiological difference between humans and the mouse model. Among the downregulated proteins, the complement factor D (CFD) showed monotonic decrease that was in good agreement with the enzyme-linked immunosorbent assay. These results suggest that the comprehensive and systematic proteomic approach may be promising in terms of the selection and evaluation of biomarker candidates." @default.
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• W2489071766 date "2016-01-01" @default.
• W2489071766 modified "2023-09-28" @default.
• W2489071766 title "Discovery and Evaluation of Biomarkers for Atherosclerosis" @default.
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• W2489071766 doi "https://doi.org/10.1007/978-4-431-55894-1_10" @default.
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