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• W2489128448 abstract "In this chapter we describe three examples of how the interplay between fundamental scientific discoveries and clinical experience has driven the development of innovative treatments in the field of oncology over the past two decades. The first case study concerns the development of the anti-CD20 monoclonal antibody (mAb) rituximab, the first mAb to be approved for therapeutic use and the first single agent to be approved specifically for the treatment of a B cell lymphoma. In recent years, translational research has focused on elucidating the molecular mechanisms underlying rituximab's therapeutic action in order to develop novel agents with enhanced therapeutic profiles. The second case describes how the treatment of a small minority of patients with non-small cell lung cancer expressing chromosomal rearrangements of anaplastic lymphoma kinase was transformed by the clinical development of crizotinib, a small molecule tyrosine kinase inhibitor. However, as with many molecularly targeted treatments, drug resistance to crizotinib usually develops with time, and therefore recent translational research efforts have been directed toward developing agents to overcome resistance mechanisms. Our third case describes how immuno-oncology has evolved as a powerful approach to the treatment of advanced solid tumors. Significant progress in our understanding of the mechanisms underlying tumor-mediated immune resistance has led to the development of antagonist mAbs targeted toward “immune checkpoint” molecules. Several agents, including ipilimumab (anti-CTLA-4) and pembrolizumab (anti-PD-1), have already been approved for the treatment of advanced or unresectable melanoma, where durable, potentially curative responses have been observed in some patients. Translational medicine will undoubtedly play a key role in the future development of rationalized combination strategies in order to improve therapeutic outcomes in a broader range of histologies." @default.
• W2489128448 created "2016-08-23" @default.
• W2489128448 creator A5006952731 @default.
• W2489128448 creator A5034087043 @default.
• W2489128448 creator A5068499081 @default.
• W2489128448 date "2016-01-01" @default.
• W2489128448 modified "2023-10-12" @default.
• W2489128448 title "Translational Medicine Case Studies and Reports" @default.
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• W2489128448 cites W1519176158 @default.
• W2489128448 cites W1543725972 @default.
• W2489128448 cites W1575513830 @default.
• W2489128448 cites W1580026313 @default.
• W2489128448 cites W1614597080 @default.
• W2489128448 cites W1897592311 @default.
• W2489128448 cites W1915689252 @default.
• W2489128448 cites W1935886040 @default.
• W2489128448 cites W1952288345 @default.
• W2489128448 cites W1963633622 @default.
• W2489128448 cites W1965215390 @default.
• W2489128448 cites W1965962344 @default.
• W2489128448 cites W1971208896 @default.
• W2489128448 cites W1971637045 @default.
• W2489128448 cites W1974903221 @default.
• W2489128448 cites W1988314473 @default.
• W2489128448 cites W1992546156 @default.
• W2489128448 cites W1993428519 @default.
• W2489128448 cites W1996710470 @default.
• W2489128448 cites W1997476230 @default.
• W2489128448 cites W2009109361 @default.
• W2489128448 cites W2010329820 @default.
• W2489128448 cites W2012104766 @default.
• W2489128448 cites W2029208213 @default.
• W2489128448 cites W2029765161 @default.
• W2489128448 cites W2037139573 @default.
• W2489128448 cites W2038056960 @default.
• W2489128448 cites W2039226259 @default.
• W2489128448 cites W2040636001 @default.
• W2489128448 cites W2043696829 @default.
• W2489128448 cites W2043946207 @default.
• W2489128448 cites W2044360617 @default.
• W2489128448 cites W2052546787 @default.
• W2489128448 cites W2053725511 @default.
• W2489128448 cites W2055402151 @default.
• W2489128448 cites W2066417528 @default.
• W2489128448 cites W2066671159 @default.
• W2489128448 cites W206701898 @default.
• W2489128448 cites W2070059266 @default.
• W2489128448 cites W2072953725 @default.
• W2489128448 cites W2079142824 @default.
• W2489128448 cites W2091057822 @default.
• W2489128448 cites W2094366129 @default.
• W2489128448 cites W2094804545 @default.
• W2489128448 cites W2097995306 @default.
• W2489128448 cites W2104830962 @default.
• W2489128448 cites W2108669049 @default.
• W2489128448 cites W2109490990 @default.
• W2489128448 cites W2109775395 @default.
• W2489128448 cites W2112476236 @default.
• W2489128448 cites W2112601576 @default.
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• W2489128448 cites W2120319857 @default.
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• W2489128448 cites W2123727052 @default.
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• W2489128448 cites W2134677113 @default.
• W2489128448 cites W2134787029 @default.
• W2489128448 cites W2136245016 @default.
• W2489128448 cites W2136549983 @default.
• W2489128448 cites W2136859769 @default.
• W2489128448 cites W2138134458 @default.
• W2489128448 cites W2139110945 @default.
• W2489128448 cites W2139236349 @default.
• W2489128448 cites W2143163879 @default.
• W2489128448 cites W2144995154 @default.
• W2489128448 cites W2150424194 @default.
• W2489128448 cites W2153345506 @default.
• W2489128448 cites W2161821474 @default.
• W2489128448 cites W2162856391 @default.
• W2489128448 cites W2164355106 @default.
• W2489128448 cites W2169691338 @default.
• W2489128448 cites W2170938637 @default.
• W2489128448 cites W2317038275 @default.
• W2489128448 cites W2494321613 @default.
• W2489128448 cites W2745070795 @default.
• W2489128448 cites W2991834586 @default.
• W2489128448 cites W3145077989 @default.
• W2489128448 cites W60759546 @default.
• W2489128448 cites W76624571 @default.
• W2489128448 cites W85464595 @default.
• W2489128448 cites W2246441943 @default.
• W2489128448 doi "https://doi.org/10.1016/b978-0-12-803460-6.00006-4" @default.
• W2489128448 hasPublicationYear "2016" @default.
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