Matches in SemOpenAlex for { <https://semopenalex.org/work/W2489175956> ?p ?o ?g. }
- W2489175956 endingPage "194" @default.
- W2489175956 startingPage "175" @default.
- W2489175956 abstract "This chapter discusses the existence of newly described polyphosphoinositides that are responsive to mitogen stimulation or oncogenic transformation in cultured mammalian cells. The time course of production of novel polyphosphoinositides suggests that they are important signaling molecules in the signal transduction pathway for mitogenic protein tyrosine kinases. The structures of polyphosphoinositides, PtdIns-3,4-P2 and PtdIns-3,4,5-P3, provide evidence that they are not direct precursors for the well-characterized second messenger Ins-1,4,5-P3. Because the purified Ptdlns 3-kinase can utilize Ptdlns, PtdIns-4-P, and PtdIns-4,5-P2 as substrates in vitro, it seems likely that activation of Ptdlns 3-kinase may result in the generation of multiple signals that branch off from the conventional polyphosphoinositide pathway. Polyphosphoinositides have been extensively studied because of their involvement in intracellular signaling. Phosphatidylinositol 4,5-bisphosphate and phosphatidyHnositol 4-phosphate are precursors of the second messenger pathway involving inositol 1,4,5-trisphosphate and diacylglycerol." @default.
- W2489175956 created "2016-08-23" @default.
- W2489175956 creator A5016369814 @default.
- W2489175956 creator A5057032257 @default.
- W2489175956 date "1992-01-01" @default.
- W2489175956 modified "2023-09-26" @default.
- W2489175956 title "Phosphatidylinositol 3-kinase: A Novel Signal Transduction Pathway?" @default.
- W2489175956 cites W1499576097 @default.
- W2489175956 cites W1505319644 @default.
- W2489175956 cites W1527514147 @default.
- W2489175956 cites W1535346776 @default.
- W2489175956 cites W1545503281 @default.
- W2489175956 cites W1549868924 @default.
- W2489175956 cites W1554276067 @default.
- W2489175956 cites W1565022554 @default.
- W2489175956 cites W1574140047 @default.
- W2489175956 cites W1575516545 @default.
- W2489175956 cites W1595741577 @default.
- W2489175956 cites W1603755042 @default.
- W2489175956 cites W1608043665 @default.
- W2489175956 cites W1611789306 @default.
- W2489175956 cites W1629600409 @default.
- W2489175956 cites W1761817889 @default.
- W2489175956 cites W1786665655 @default.
- W2489175956 cites W1789958833 @default.
- W2489175956 cites W1805681920 @default.
- W2489175956 cites W1931293178 @default.
- W2489175956 cites W1938975553 @default.
- W2489175956 cites W1968966545 @default.
- W2489175956 cites W1970575648 @default.
- W2489175956 cites W1971333358 @default.
- W2489175956 cites W1972617251 @default.
- W2489175956 cites W1975642651 @default.
- W2489175956 cites W1985187767 @default.
- W2489175956 cites W1986694073 @default.
- W2489175956 cites W1997910286 @default.
- W2489175956 cites W1997962878 @default.
- W2489175956 cites W1998451617 @default.
- W2489175956 cites W2004051730 @default.
- W2489175956 cites W2005529016 @default.
- W2489175956 cites W2005536723 @default.
- W2489175956 cites W2009671832 @default.
- W2489175956 cites W2011844896 @default.
- W2489175956 cites W2013456957 @default.
- W2489175956 cites W2017499074 @default.
- W2489175956 cites W2023441605 @default.
- W2489175956 cites W2027156965 @default.
- W2489175956 cites W2028650907 @default.
- W2489175956 cites W2033436103 @default.
- W2489175956 cites W2035016671 @default.
- W2489175956 cites W2037239040 @default.
- W2489175956 cites W2044148403 @default.
- W2489175956 cites W2045956897 @default.
- W2489175956 cites W2050759207 @default.
- W2489175956 cites W2051422927 @default.
- W2489175956 cites W2059795432 @default.
- W2489175956 cites W2060043725 @default.
- W2489175956 cites W2065447875 @default.
- W2489175956 cites W2074571771 @default.
- W2489175956 cites W2078835916 @default.
- W2489175956 cites W2090940799 @default.
- W2489175956 cites W2092045274 @default.
- W2489175956 cites W2105490477 @default.
- W2489175956 cites W2106495708 @default.
- W2489175956 cites W2112506274 @default.
- W2489175956 cites W2127947223 @default.
- W2489175956 cites W2128097881 @default.
- W2489175956 cites W2135533535 @default.
- W2489175956 cites W2143901563 @default.
- W2489175956 cites W2170264926 @default.
- W2489175956 cites W2199396374 @default.
- W2489175956 cites W2255612709 @default.
- W2489175956 cites W2257951877 @default.
- W2489175956 cites W2260076009 @default.
- W2489175956 cites W2314217713 @default.
- W2489175956 cites W2339308294 @default.
- W2489175956 cites W2402249489 @default.
- W2489175956 doi "https://doi.org/10.1016/b978-0-12-150403-8.50010-5" @default.
- W2489175956 hasPublicationYear "1992" @default.
- W2489175956 type Work @default.
- W2489175956 sameAs 2489175956 @default.
- W2489175956 citedByCount "0" @default.
- W2489175956 crossrefType "book-chapter" @default.
- W2489175956 hasAuthorship W2489175956A5016369814 @default.
- W2489175956 hasAuthorship W2489175956A5057032257 @default.
- W2489175956 hasConcept C163235415 @default.
- W2489175956 hasConcept C170493617 @default.
- W2489175956 hasConcept C184235292 @default.
- W2489175956 hasConcept C195794163 @default.
- W2489175956 hasConcept C2777427919 @default.
- W2489175956 hasConcept C2778618036 @default.
- W2489175956 hasConcept C2780610907 @default.
- W2489175956 hasConcept C36020004 @default.
- W2489175956 hasConcept C42362537 @default.
- W2489175956 hasConcept C55493867 @default.
- W2489175956 hasConcept C62478195 @default.
- W2489175956 hasConcept C86803240 @default.
- W2489175956 hasConcept C95444343 @default.