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- W2489185469 endingPage "R113" @default.
- W2489185469 startingPage "R101" @default.
- W2489185469 abstract "Human germ cell development is regulated in a spatio-temporal manner by complex regulatory networks. Here, we summarize results obtained in germ cell tumors and respective cell lines and try to pinpoint similarities to normal germ cell development. This comparison allows speculating about the critical and error-prone mechanisms, which when disturbed, lead to the development of germ cell tumors. Short after specification, primordial germ cells express markers of pluripotency, which, in humans, persists up to the stage of fetal/infantile spermatogonia. Aside from the rare spermatocytic tumors, virtually all seminomas and embryonal carcinomas express markers of pluripotency and show signs of pluripotency or totipotency. Therefore, it appears that proper handling of the pluripotency program appears to be the most critical step in germ cell development in terms of tumor biology. Furthermore, data from mice reveal that germline cells display an epigenetic signature, which is highly similar to pluripotent cells. This signature (poised histone code, DNA hypomethylation) is required for the rapid induction of toti- and pluripotency upon fertilization. We propose that adult spermatogonial cells, when exposed to endocrine disruptors or epigenetic active substances, are prone to reinitiate the pluripotency program, giving rise to a germ cell tumor. The fact that pluripotent cells can be derived from adult murine and human testicular cells further corroborates this idea." @default.
- W2489185469 created "2016-08-23" @default.
- W2489185469 creator A5015796348 @default.
- W2489185469 creator A5029479751 @default.
- W2489185469 creator A5051141861 @default.
- W2489185469 creator A5081843615 @default.
- W2489185469 date "2016-10-01" @default.
- W2489185469 modified "2023-09-28" @default.
- W2489185469 title "Elucidating human male germ cell development by studying germ cell cancer" @default.
- W2489185469 cites W1485430712 @default.
- W2489185469 cites W1500559236 @default.
- W2489185469 cites W1517981219 @default.
- W2489185469 cites W1558096440 @default.
- W2489185469 cites W1832914678 @default.
- W2489185469 cites W1849946000 @default.
- W2489185469 cites W1964959920 @default.
- W2489185469 cites W1968494280 @default.
- W2489185469 cites W1968931043 @default.
- W2489185469 cites W1972755465 @default.
- W2489185469 cites W1972755526 @default.
- W2489185469 cites W1976321580 @default.
- W2489185469 cites W1977476921 @default.
- W2489185469 cites W1977828694 @default.
- W2489185469 cites W1977962128 @default.
- W2489185469 cites W1978700171 @default.
- W2489185469 cites W1979219645 @default.
- W2489185469 cites W1982102692 @default.
- W2489185469 cites W1982429165 @default.
- W2489185469 cites W1982566800 @default.
- W2489185469 cites W1983803401 @default.
- W2489185469 cites W1985872661 @default.
- W2489185469 cites W1986580901 @default.
- W2489185469 cites W1987941144 @default.
- W2489185469 cites W1989027475 @default.
- W2489185469 cites W1992501173 @default.
- W2489185469 cites W1994830504 @default.
- W2489185469 cites W1998352081 @default.
- W2489185469 cites W1998841413 @default.
- W2489185469 cites W1998949868 @default.
- W2489185469 cites W2002564923 @default.
- W2489185469 cites W2007003847 @default.
- W2489185469 cites W2013017545 @default.
- W2489185469 cites W2013518855 @default.
- W2489185469 cites W2015489559 @default.
- W2489185469 cites W2016479148 @default.
- W2489185469 cites W2016971867 @default.
- W2489185469 cites W2017339593 @default.
- W2489185469 cites W2017840637 @default.
- W2489185469 cites W2021528928 @default.
- W2489185469 cites W2022223287 @default.
- W2489185469 cites W2023844789 @default.
- W2489185469 cites W2024883189 @default.
- W2489185469 cites W2026084160 @default.
- W2489185469 cites W2026529460 @default.
- W2489185469 cites W2027011084 @default.
- W2489185469 cites W2028367089 @default.
- W2489185469 cites W2028887145 @default.
- W2489185469 cites W2029346581 @default.
- W2489185469 cites W2030523067 @default.
- W2489185469 cites W2031976805 @default.
- W2489185469 cites W2034932185 @default.
- W2489185469 cites W2035143183 @default.
- W2489185469 cites W2035967806 @default.
- W2489185469 cites W2036654302 @default.
- W2489185469 cites W2037818631 @default.
- W2489185469 cites W2040511639 @default.
- W2489185469 cites W2043004382 @default.
- W2489185469 cites W2045557362 @default.
- W2489185469 cites W2046197443 @default.
- W2489185469 cites W2059145054 @default.
- W2489185469 cites W2059780090 @default.
- W2489185469 cites W2059939423 @default.
- W2489185469 cites W2061776278 @default.
- W2489185469 cites W2066794008 @default.
- W2489185469 cites W2067102637 @default.
- W2489185469 cites W2068518433 @default.
- W2489185469 cites W2068823798 @default.
- W2489185469 cites W2070807361 @default.
- W2489185469 cites W2071365780 @default.
- W2489185469 cites W2073453074 @default.
- W2489185469 cites W2073587729 @default.
- W2489185469 cites W2073983698 @default.
- W2489185469 cites W2074134128 @default.
- W2489185469 cites W2075233530 @default.
- W2489185469 cites W2080241168 @default.
- W2489185469 cites W2085001173 @default.
- W2489185469 cites W2086943348 @default.
- W2489185469 cites W2087643679 @default.
- W2489185469 cites W2087693352 @default.
- W2489185469 cites W2087739768 @default.
- W2489185469 cites W2088218995 @default.
- W2489185469 cites W2090510808 @default.
- W2489185469 cites W2091365246 @default.
- W2489185469 cites W2091385966 @default.
- W2489185469 cites W2092243554 @default.
- W2489185469 cites W2092791039 @default.
- W2489185469 cites W2097371988 @default.
- W2489185469 cites W2097875577 @default.