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• W2489190067 abstract "Abstract As part of regenerative medicine, tooth organ engineering raises a series of distinct biological challenges to be solved before any clinical development can be considered. These include the finding of easily available cell sources, the maintenance of odontogenetic properties of cultured cells, and the synchronization of very distinct biological processes. Summarizing the main achievements concerning the engineering of a complete tooth and attachment tissues (crown and root formation, functional differentiation of odontoblasts, ameloblasts and cementoblasts, periodontium attached to newly formed bone), this review aims to point out the main questions that still need to be addressed. Taking into account the specificities of tooth development, the search for competent cells to be used for engineering will need to determine the simplest minimal requirements that have to be preserved. The loss of odontogenic properties in vitro raises the question of possible cell selection versus the relationship between microenvironment and cell phenotype. Addressing these questions will require a better understanding of cell homeostasis and heterogeneity during tooth development and engineering. Although methodological adjustments will be necessary when changing the cell sources, a lot remains to be done, still working with embryonic mouse dental cells. With this system, it will be necessary to search for the molecular mechanisms sustaining the “instructive potential” of the epithelium, as required for the specification of mesenchymal cells, the initiation of odontogenesis and later, the specification of a dental epithelial-mesenchymal junction." @default.
• W2489190067 created "2016-08-23" @default.
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• W2489190067 date "2015-01-01" @default.
• W2489190067 modified "2023-09-28" @default.
• W2489190067 title "Tooth Organ Engineering" @default.
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• W2489190067 doi "https://doi.org/10.1016/b978-0-12-397157-9.00032-1" @default.
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