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- W2489219006 abstract "Immunohistochemical localization of adducts can be accomplished using antiserum developed and characterized for quantitative immunoassays. The 3-(cystein-S-yl)acetaminophen protein adduct is associated with the toxicity of the prototype hepatotoxin, acetaminophen. Immunohistochemical localization of this adduct is described to illustrate the technique as an adjunct to other methods in the assessment of toxicity. This method provides direct correlation between presence of adduct and morphologic evidence of cell injury. Microwave irradiation was pioneered as a fixation method to simultaneously preserve tissue structure and adduct antigenicity." @default.
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- W2489219006 date "1990-12-26" @default.
- W2489219006 modified "2023-09-27" @default.
- W2489219006 title "Immunohistochemical Detection of Antigenic Biomarkers in Microwave-Fixed Target Tissues" @default.
- W2489219006 doi "https://doi.org/10.1021/bk-1990-0451.ch030" @default.
- W2489219006 hasPublicationYear "1990" @default.
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