Matches in SemOpenAlex for { <https://semopenalex.org/work/W2489231412> ?p ?o ?g. }
- W2489231412 abstract "Publisher Summary Nitric oxide (NO) is a bioactive gas produced through the conversion of L-arginine to L-citrulline by nitric oxide synthase (NOS). It is a diatomic signaling molecule that diffuses rapidly through tissues and cells. NO targets metabolic pathways in vascular cells that stimulate neovascularization, wound healing, blood flow, and cytoprotection. Previously, degradation of downstream effectors and sequestration of NO were the only known means to modulate physiologic NO signaling. Studies of the angiogenesis inhibitor thrombospondin-1 (TSP1) led to discovery of a major physiological pathway mediated by its receptor CD47 that limits NO/cGMP signaling in endothelial and vascular smooth muscle cells and platelets. This pathway tonically limits the ability of NO to increase perfusion of healthy tissue. Following injury, TSP1 initially plays an important role to limit bleeding through its effects on platelet activation and vasoconstriction, but these activities of TSP1 become a liability in the context of ischemia, reperfusion injury, or aging. Agents that block TSP1-CD47 signaling are cytoprotective under these conditions and improve both the acute maintenance of blood flow and long-term tissue survival. TSP1 also has anti-angiogenic activity that limits neovascularization of tumors. Tumors frequently exhibit a loss of TSP1 expression, and its reexpression inhibits tumor angiogenesis." @default.
- W2489231412 created "2016-08-23" @default.
- W2489231412 creator A5013768407 @default.
- W2489231412 creator A5029263699 @default.
- W2489231412 creator A5031078822 @default.
- W2489231412 date "2010-01-01" @default.
- W2489231412 modified "2023-09-27" @default.
- W2489231412 title "Nitric Oxide Signaling in Vascular Cells is Regulated through CD47 by Thrombospondin-1" @default.
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