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- W2489242570 abstract "The cornea plays important roles in the eye since it not only maintains the ocular pressure and protects against different aggressions and forces but constitutes the primary lens in many animals’ eyes as well. In order to fulfill these extremely crucial functions, the cornea requires sophisticated structures called the epithelium, Bowman’s membrane, the stroma, Descement’s layer, and the endothelium. The complexity of this tissue is such that despite many efforts, it has not been possible to obtain clinically viable corneas in the laboratory yet. Vitamin C or L-ascorbic acid is an essential vitamin and a water-soluble important nutrient many animals chemically synthesize from glucose by means of enzymatic reactions, with L-gulono-γ-lactone oxidase being the last step. Among the multiple roles played by this vitamin, its primary functions are to act as a cofactor for reactions requiring reduced iron or copper metalloenzyme and as a protective antioxidant that operates in the aqueous phases, both intra- and extracellularly. Ocular tissues, particularly the cornea, concentrate vitamin C, which might suggest that the cornea’s different structures need this vitamin to fulfill their roles. In this work, we present scientific evidence of the critical roles that ascorbic acid performs in maintaining the functions and ultrastructures of the corneal epithelium, the stroma, and the endothelium." @default.
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- W2489242570 date "2014-01-01" @default.
- W2489242570 modified "2023-10-01" @default.
- W2489242570 title "Vitamin C Functions in the Cornea" @default.
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- W2489242570 doi "https://doi.org/10.1016/b978-0-12-401717-7.00031-9" @default.
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