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- W2489337457 abstract "Methyladenine (5 mM) inhibits endogenous protein degradation in isolated rat hepatocytes by about 60%, while having no adverse effect on the degradation of an exogenous protein (asialofetuin), on protein synthesis, or on intracellular ATP levels. 3-Methyladenine appears to act specifically upon the au- tophagic/lysosomal pathway of degradation, as judged from its lack of effect in the presence of amino acids or a lysosomotropic amine (propylamine). The effect of the purine is not mediated by amino acids because the inhibition of protein degradation is ac- companied by a significant depression of intracellular amino acid levels. The ability of 3-methyladenine to suppress the formation of electron microscopically visible autophagosomes suggests that it may be regarded as a specific inhibitor of autophagy." @default.
- W2489337457 created "2016-08-23" @default.
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- W2489337457 date "2016-01-01" @default.
- W2489337457 modified "2023-09-27" @default.
- W2489337457 title "3-Methyladenine: Specific inhibitor protein degradation in isolated rat )" @default.
- W2489337457 hasPublicationYear "2016" @default.
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