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- W2489402574 abstract "Essential oils are produced by plants and have been shown to have repellent, attractant or insecticidal properties. It is presumed that these effects are produced through their interaction with octopamine receptors. Octopamine, an important biogenic monoamine in insects, where it functions as a neurotransmitter, neuromodulator, and a neurohormone. Octopamine activates G protein-coupled receptors (GPCRs), which, in turn, activate or inhibit various signal transduction pathways. Here the α-adrenergic-like octopamine receptor from Periplaneta americana (Pa oa1) was expressed in a yeast cell line (Saccharomyces cerevisiae). This is the first time, to our knowledge, that an insect receptor has been expressed in yeast cells. We determined that a variety of monoterpenoids and related aromatic compounds interact with this Pa oa1, and that most of these compounds act as inverse agonists to this constitutively active receptor. However, we observed that the aromatic monoterpenoid, carvacrol, acts as a positive modulator of Pa oa1." @default.
- W2489402574 created "2016-08-23" @default.
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- W2489402574 date "2014-01-01" @default.
- W2489402574 modified "2023-09-23" @default.
- W2489402574 title "Investigating the Effect of Plant Essential Oils against the American Cockroach Octopamine Receptor (Pa oa1) Expressed in Yeast" @default.
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- W2489402574 doi "https://doi.org/10.1021/bk-2014-1172.ch009" @default.
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