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- W2489474755 abstract "The present study was carried out to evaluate the photochemical, antioxidant activity, antimicrobial and cytotoxicity potential of methanol extract of Hemidesmus indicus (HIM) in various in vitro systems. Phytochemical screening revealed the presence of glycoside, terpenoid and reducing sugar. Antioxidant and free radical scavenging activities of HIM were assessed by using nitric oxide scavenging capacity, reducing power capacity, cupric reducing antioxidant capacity and determining the phenolic and flavonoid content. HIM exhibited significant nitric oxide scavenging capacity with IC50 value 26.29 μg/mL where IC50 value of ascorbic acid and quercetin were found 5.47 μg/mL and 15.24 μg/mL respectively. In the case of reducing power assessment, concentration dependent manner was marked where percentage was 255.43. A moderate effect was observed in cupric ion reducing capability test. This HIM also contains high levels of phenol and low portion of flavonoid. Antimicrobial activities of HIM were carried out using disc diffusion methods with gram positive and gram negative bacteria. HIM showed moderate to good antimicrobial activity against some positive and negative organisms with an average zone of inhibition of 6.5-10 μg/disc. Cytotoxicity test was carried out by brine shrimp where per cent mortality of this extract showed signs of good anticancer potential and LC50 was 9.79. The results obtained in the present study indicate that the HIM can be a potential source of a natural cytotoxic, antioxidant and good antimicrobial agent." @default.
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- W2489474755 date "2012-01-01" @default.
- W2489474755 modified "2023-09-23" @default.
- W2489474755 title "In vitro antioxidant, antimicrobial and cytotoxicity screening of methanol extract of 'Hemidesmus indicus'" @default.
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