Matches in SemOpenAlex for { <https://semopenalex.org/work/W2489491424> ?p ?o ?g. }
- W2489491424 endingPage "S209" @default.
- W2489491424 startingPage "S205" @default.
- W2489491424 abstract "Severe hypoglycemia is recognized to be one of the strongest predictors of macrovascular events, adverse clinical outcomes, and mortality in patients with type 2 diabetes. However, it is uncertain whether a direct pathophysiological link exists or whether hypoglycemia is primarily a marker of vulnerability to these events. Large clinical trials have reported an increased hazard ratio for all-cause mortality and cardiovascular events in patients with type 2 diabetes and severe hypoglycemia, but such an association has not been demonstrated in prospective trials of people with type 1 diabetes. Several cardiovascular effects occur during hypoglycemia either as a result of low blood glucose levels per se or through activation of the sympathoadrenal response: hemodynamic changes with an increase in cardiac work load and potential attenuation of myocardial perfusion, electrophysiological changes that may be arrhythmogenic, induction of a prothrombotic state, and release of inflammatory markers. Although the potential for a causal relationship has been demonstrated in mechanistic studies, the evidence from large prospective studies that hypoglycemia is a major causal contributor to cardiovascular events is limited to date. Other preexisting cardiovascular risk factors in addition to hypoglycemia may be the major link to the final cardiovascular event, but a low blood glucose level can trigger these events in patients with a high cardiovascular risk." @default.
- W2489491424 created "2016-08-23" @default.
- W2489491424 creator A5010285104 @default.
- W2489491424 creator A5050650061 @default.
- W2489491424 creator A5052329017 @default.
- W2489491424 date "2016-07-16" @default.
- W2489491424 modified "2023-10-16" @default.
- W2489491424 title "Hypoglycemia and Cardiovascular Risk: Is There a Major Link?" @default.
- W2489491424 cites W1526927233 @default.
- W2489491424 cites W1966288430 @default.
- W2489491424 cites W1967159569 @default.
- W2489491424 cites W1968552143 @default.
- W2489491424 cites W1977840198 @default.
- W2489491424 cites W1980136314 @default.
- W2489491424 cites W1981612300 @default.
- W2489491424 cites W1994810473 @default.
- W2489491424 cites W2015544031 @default.
- W2489491424 cites W2020396351 @default.
- W2489491424 cites W2023885527 @default.
- W2489491424 cites W2041147941 @default.
- W2489491424 cites W2042767418 @default.
- W2489491424 cites W2068907080 @default.
- W2489491424 cites W2076573528 @default.
- W2489491424 cites W2076679703 @default.
- W2489491424 cites W2085546759 @default.
- W2489491424 cites W2090015923 @default.
- W2489491424 cites W2090816085 @default.
- W2489491424 cites W2097995302 @default.
- W2489491424 cites W2105390517 @default.
- W2489491424 cites W2108146012 @default.
- W2489491424 cites W2109942999 @default.
- W2489491424 cites W2111618576 @default.
- W2489491424 cites W2115274363 @default.
- W2489491424 cites W2115968076 @default.
- W2489491424 cites W2125468958 @default.
- W2489491424 cites W2127636367 @default.
- W2489491424 cites W2128592897 @default.
- W2489491424 cites W2130161108 @default.
- W2489491424 cites W2144610870 @default.
- W2489491424 cites W2147623587 @default.
- W2489491424 cites W2149914043 @default.
- W2489491424 cites W2153957843 @default.
- W2489491424 cites W2157363221 @default.
- W2489491424 cites W2158666727 @default.
- W2489491424 cites W2160262821 @default.
- W2489491424 cites W2163051634 @default.
- W2489491424 cites W2163966221 @default.
- W2489491424 cites W2171294019 @default.
- W2489491424 cites W2323302281 @default.
- W2489491424 cites W2397917380 @default.
- W2489491424 cites W4252271922 @default.
- W2489491424 doi "https://doi.org/10.2337/dcs15-3014" @default.
- W2489491424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27440834" @default.
- W2489491424 hasPublicationYear "2016" @default.
- W2489491424 type Work @default.
- W2489491424 sameAs 2489491424 @default.
- W2489491424 citedByCount "85" @default.
- W2489491424 countsByYear W24894914242016 @default.
- W2489491424 countsByYear W24894914242017 @default.
- W2489491424 countsByYear W24894914242018 @default.
- W2489491424 countsByYear W24894914242019 @default.
- W2489491424 countsByYear W24894914242020 @default.
- W2489491424 countsByYear W24894914242021 @default.
- W2489491424 countsByYear W24894914242022 @default.
- W2489491424 countsByYear W24894914242023 @default.
- W2489491424 crossrefType "journal-article" @default.
- W2489491424 hasAuthorship W2489491424A5010285104 @default.
- W2489491424 hasAuthorship W2489491424A5050650061 @default.
- W2489491424 hasAuthorship W2489491424A5052329017 @default.
- W2489491424 hasBestOaLocation W24894914241 @default.
- W2489491424 hasConcept C126322002 @default.
- W2489491424 hasConcept C134018914 @default.
- W2489491424 hasConcept C164705383 @default.
- W2489491424 hasConcept C177713679 @default.
- W2489491424 hasConcept C188816634 @default.
- W2489491424 hasConcept C197934379 @default.
- W2489491424 hasConcept C2777180221 @default.
- W2489491424 hasConcept C2780668416 @default.
- W2489491424 hasConcept C555293320 @default.
- W2489491424 hasConcept C71924100 @default.
- W2489491424 hasConceptScore W2489491424C126322002 @default.
- W2489491424 hasConceptScore W2489491424C134018914 @default.
- W2489491424 hasConceptScore W2489491424C164705383 @default.
- W2489491424 hasConceptScore W2489491424C177713679 @default.
- W2489491424 hasConceptScore W2489491424C188816634 @default.
- W2489491424 hasConceptScore W2489491424C197934379 @default.
- W2489491424 hasConceptScore W2489491424C2777180221 @default.
- W2489491424 hasConceptScore W2489491424C2780668416 @default.
- W2489491424 hasConceptScore W2489491424C555293320 @default.
- W2489491424 hasConceptScore W2489491424C71924100 @default.
- W2489491424 hasIssue "Supplement_2" @default.
- W2489491424 hasLocation W24894914241 @default.
- W2489491424 hasLocation W24894914242 @default.
- W2489491424 hasOpenAccess W2489491424 @default.
- W2489491424 hasPrimaryLocation W24894914241 @default.
- W2489491424 hasRelatedWork W1563850031 @default.
- W2489491424 hasRelatedWork W2015926965 @default.
- W2489491424 hasRelatedWork W2233866314 @default.