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• W2489507000 endingPage "201" @default.
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• W2489507000 abstract "Precursor mRNA (pre-mRNA) splicing proceeds by two consecutive transesterification reactions via a lariat-intron intermediate. Here we present the 3.8 Å cryo-electron microscopy structure of the spliceosome immediately after lariat formation. The 5'-splice site is cleaved but remains close to the catalytic Mg2+ site in the U2/U6 small nuclear RNA (snRNA) triplex, and the 5'-phosphate of the intron nucleotide G(+1) is linked to the branch adenosine 2'OH. The 5'-exon is held between the Prp8 amino-terminal and linker domains, and base-pairs with U5 snRNA loop 1. Non-Watson-Crick interactions between the branch helix and 5'-splice site dock the branch adenosine into the active site, while intron nucleotides +3 to +6 base-pair with the U6 snRNA ACAGAGA sequence. Isy1 and the step-one factors Yju2 and Cwc25 stabilize docking of the branch helix. The intron downstream of the branch site emerges between the Prp8 reverse transcriptase and linker domains and extends towards the Prp16 helicase, suggesting a plausible mechanism of remodelling before exon ligation." @default.
• W2489507000 created "2016-08-23" @default.
• W2489507000 creator A5035477681 @default.
• W2489507000 creator A5056271884 @default.
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• W2489507000 creator A5068936914 @default.
• W2489507000 creator A5071998711 @default.
• W2489507000 creator A5075304072 @default.
• W2489507000 date "2016-07-26" @default.
• W2489507000 modified "2023-09-26" @default.
• W2489507000 title "Cryo-EM structure of the spliceosome immediately after branching" @default.
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• W2489507000 doi "https://doi.org/10.1038/nature19316" @default.
• W2489507000 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5156311" @default.
• W2489507000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27459055" @default.
• W2489507000 hasPublicationYear "2016" @default.
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