Matches in SemOpenAlex for { <https://semopenalex.org/work/W2489516684> ?p ?o ?g. }
- W2489516684 endingPage "118" @default.
- W2489516684 startingPage "85" @default.
- W2489516684 abstract "Parental care influences development across mammals. In humans, such influences include effects on phenotypes, such as stress reactivity, that determine individual differences in the vulnerability for affective disorders. Thus, variations in maternal care regulate hippocampal glucocorticoid receptor expression resulting in stable individual differences in hypothalamic–pituitary–adrenal responses to stress. In humans, childhood maltreatment associates with decreased hippocampal glucocorticoid receptor expression and increased stress responses in adulthood. We review the evidence suggesting that such effects are mediated by epigenetic mechanisms, including DNA methylation and hydroxymethylation across glucocorticoid receptor promoter regions as well as those for genes encoding for hypothalamic releasing factors. The existing evidence is consistent with the idea that parental influences establish stable phenotypic variation in the offspring through effects on intracellular signaling pathways that regulate the epigenetic state and function of specific regions of the genome. We discuss the relevance of these and other findings for the “environmental epigenetics” hypothesis. Finally, we examine studies examining the transgenerational transmission of individual differences in parent care, which provides insights into the neurobiological and epigenetic mechanisms for non-genomic processes of transmission." @default.
- W2489516684 created "2016-08-23" @default.
- W2489516684 creator A5002118289 @default.
- W2489516684 creator A5005240876 @default.
- W2489516684 creator A5034400760 @default.
- W2489516684 creator A5036400477 @default.
- W2489516684 creator A5046707379 @default.
- W2489516684 creator A5058548765 @default.
- W2489516684 date "2013-01-01" @default.
- W2489516684 modified "2023-09-27" @default.
- W2489516684 title "The Epigenetics of Parental Effects" @default.
- W2489516684 cites W1490615017 @default.
- W2489516684 cites W1511815964 @default.
- W2489516684 cites W155070316 @default.
- W2489516684 cites W1551014807 @default.
- W2489516684 cites W1583511773 @default.
- W2489516684 cites W1619716059 @default.
- W2489516684 cites W1695801694 @default.
- W2489516684 cites W1722045455 @default.
- W2489516684 cites W175480866 @default.
- W2489516684 cites W1784857457 @default.
- W2489516684 cites W1868814633 @default.
- W2489516684 cites W1886309510 @default.
- W2489516684 cites W1908835442 @default.
- W2489516684 cites W191083658 @default.
- W2489516684 cites W1954049365 @default.
- W2489516684 cites W1958299123 @default.
- W2489516684 cites W1965160371 @default.
- W2489516684 cites W1965235291 @default.
- W2489516684 cites W1965636455 @default.
- W2489516684 cites W1967340797 @default.
- W2489516684 cites W1967841068 @default.
- W2489516684 cites W1967858395 @default.
- W2489516684 cites W1970399699 @default.
- W2489516684 cites W1970607556 @default.
- W2489516684 cites W1971515004 @default.
- W2489516684 cites W1971922927 @default.
- W2489516684 cites W1974345876 @default.
- W2489516684 cites W1974849634 @default.
- W2489516684 cites W1977159737 @default.
- W2489516684 cites W1980273804 @default.
- W2489516684 cites W1981354816 @default.
- W2489516684 cites W1981463058 @default.
- W2489516684 cites W1981920422 @default.
- W2489516684 cites W1983693396 @default.
- W2489516684 cites W1985063313 @default.
- W2489516684 cites W1986072777 @default.
- W2489516684 cites W1986130500 @default.
- W2489516684 cites W1986853804 @default.
- W2489516684 cites W1987375729 @default.
- W2489516684 cites W1988405549 @default.
- W2489516684 cites W1989457196 @default.
- W2489516684 cites W1992571088 @default.
- W2489516684 cites W1993063708 @default.
- W2489516684 cites W1993227273 @default.
- W2489516684 cites W1993538553 @default.
- W2489516684 cites W1993811678 @default.
- W2489516684 cites W1994285890 @default.
- W2489516684 cites W1994674729 @default.
- W2489516684 cites W1996676239 @default.
- W2489516684 cites W1998270860 @default.
- W2489516684 cites W1998980503 @default.
- W2489516684 cites W1998980779 @default.
- W2489516684 cites W2000099558 @default.
- W2489516684 cites W2000415408 @default.
- W2489516684 cites W2000519327 @default.
- W2489516684 cites W2002959886 @default.
- W2489516684 cites W2003366500 @default.
- W2489516684 cites W2005590909 @default.
- W2489516684 cites W2005705238 @default.
- W2489516684 cites W2005902017 @default.
- W2489516684 cites W2006261940 @default.
- W2489516684 cites W2007041763 @default.
- W2489516684 cites W2007684630 @default.
- W2489516684 cites W2008022427 @default.
- W2489516684 cites W2008113854 @default.
- W2489516684 cites W2008833874 @default.
- W2489516684 cites W2009132290 @default.
- W2489516684 cites W2009680012 @default.
- W2489516684 cites W2010291571 @default.
- W2489516684 cites W2011094635 @default.
- W2489516684 cites W2013133792 @default.
- W2489516684 cites W2013245174 @default.
- W2489516684 cites W2014024964 @default.
- W2489516684 cites W2014623973 @default.
- W2489516684 cites W2016619393 @default.
- W2489516684 cites W2016679285 @default.
- W2489516684 cites W2018419725 @default.
- W2489516684 cites W2020113570 @default.
- W2489516684 cites W2020444746 @default.
- W2489516684 cites W2020963141 @default.
- W2489516684 cites W2022682022 @default.
- W2489516684 cites W2023287196 @default.
- W2489516684 cites W2024584416 @default.
- W2489516684 cites W2025354554 @default.
- W2489516684 cites W2027153593 @default.
- W2489516684 cites W20284704 @default.
- W2489516684 cites W2029315800 @default.