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- W2489546756 abstract "Higher doses of cefazolin are required in obese patients for preoperative antibiotic prophylaxis, owing to its low lipophilicity. An ultra high performance liquid chromatography-tandem mass spectrometry method was developed to quantify cefazolin in serum and adipose tissue from 6 obese patients undergoing cesarean delivery, and using stable-isotope labeled cefazolin as an internal standard. The method has a 2 μg/g lower limit of quantitation. The concentration in adipose tissue was 3.4 ± 1.6 μg/mL, which is less than half of the reported minimum inhibitory concentration of 8 μg/mL for cefazolin. Serum cefazolin concentrations were more than 30-fold higher than in adipose tissue." @default.
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- W2489546756 date "2016-09-01" @default.
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- W2489546756 title "Quantification of cefazolin in serum and adipose tissue by ultra high performance liquid chromatography-Tandem mass spectrometry (UHPLC–MS/MS): application to a pilot study of obese women undergoing cesarean delivery" @default.
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- W2489546756 doi "https://doi.org/10.1016/j.jchromb.2016.07.032" @default.
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