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- W2489562715 endingPage "1130" @default.
- W2489562715 startingPage "1106" @default.
- W2489562715 abstract "Abstract Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at the cell cortex and exerts pulling forces on astral microtubules to position the spindle. Early studies identified the evolutionarily conserved Gαi/ LGN /Nu MA complex as a key regulator that polarizes cortical force generators. In recent years, a combination of genetics, biochemistry, modeling, and live imaging has contributed to decipher the mechanisms of spindle orientation. Here, we highlight the dynamic nature of the assembly of this complex and discuss the molecular regulation of its localization. Remarkably, a number of LGN ‐independent mechanisms were described recently, whereas Nu MA remains central in most pathways involved in recruiting force generators at the cell cortex. We also describe the emerging role of the actin cortex in spindle orientation and discuss how dynamic astral microtubule formation is involved. We further give an overview on instructive external signals that control spindle orientation in tissues. Finally, we discuss the influence of cell geometry and mechanical forces on spindle orientation." @default.
- W2489562715 created "2016-08-23" @default.
- W2489562715 creator A5033653180 @default.
- W2489562715 creator A5052755538 @default.
- W2489562715 creator A5065530206 @default.
- W2489562715 date "2016-07-18" @default.
- W2489562715 modified "2023-10-16" @default.
- W2489562715 title "Regulation of mitotic spindle orientation: an integrated view" @default.
- W2489562715 cites W1623584754 @default.
- W2489562715 cites W1646135266 @default.
- W2489562715 cites W1864020763 @default.
- W2489562715 cites W1869363046 @default.
- W2489562715 cites W1948008900 @default.
- W2489562715 cites W1966470553 @default.
- W2489562715 cites W1967802833 @default.
- W2489562715 cites W1971221092 @default.
- W2489562715 cites W1972508744 @default.
- W2489562715 cites W1973756205 @default.
- W2489562715 cites W1976923948 @default.
- W2489562715 cites W1976964790 @default.
- W2489562715 cites W1977275853 @default.
- W2489562715 cites W1977795101 @default.
- W2489562715 cites W1978019911 @default.
- W2489562715 cites W1978968660 @default.
- W2489562715 cites W1980743267 @default.
- W2489562715 cites W1980979311 @default.
- W2489562715 cites W1982565801 @default.
- W2489562715 cites W1984932592 @default.
- W2489562715 cites W1987514898 @default.
- W2489562715 cites W1994337091 @default.
- W2489562715 cites W1997586289 @default.
- W2489562715 cites W1999286862 @default.
- W2489562715 cites W1999339871 @default.
- W2489562715 cites W2002315827 @default.
- W2489562715 cites W2002452802 @default.
- W2489562715 cites W2003067279 @default.
- W2489562715 cites W2006989477 @default.
- W2489562715 cites W2008814168 @default.
- W2489562715 cites W2008852196 @default.
- W2489562715 cites W2009611668 @default.
- W2489562715 cites W2013775624 @default.
- W2489562715 cites W2015220242 @default.
- W2489562715 cites W2019593540 @default.
- W2489562715 cites W2020857992 @default.
- W2489562715 cites W2021557163 @default.
- W2489562715 cites W2024686059 @default.
- W2489562715 cites W2026060763 @default.
- W2489562715 cites W2027084558 @default.
- W2489562715 cites W2027416251 @default.
- W2489562715 cites W2029572691 @default.
- W2489562715 cites W2030123913 @default.
- W2489562715 cites W2034301798 @default.
- W2489562715 cites W2035121505 @default.
- W2489562715 cites W2036355011 @default.
- W2489562715 cites W2038970717 @default.
- W2489562715 cites W2040152751 @default.
- W2489562715 cites W2040453897 @default.
- W2489562715 cites W2042015318 @default.
- W2489562715 cites W2045959198 @default.
- W2489562715 cites W2047417636 @default.
- W2489562715 cites W2047921488 @default.
- W2489562715 cites W2049285713 @default.
- W2489562715 cites W2050096545 @default.
- W2489562715 cites W2050688574 @default.
- W2489562715 cites W2051221246 @default.
- W2489562715 cites W2052489620 @default.
- W2489562715 cites W2052756081 @default.
- W2489562715 cites W2055613399 @default.
- W2489562715 cites W2057968441 @default.
- W2489562715 cites W2058367570 @default.
- W2489562715 cites W2059025759 @default.
- W2489562715 cites W2059841182 @default.
- W2489562715 cites W2065524217 @default.
- W2489562715 cites W2066190107 @default.
- W2489562715 cites W2070020221 @default.
- W2489562715 cites W2071418499 @default.
- W2489562715 cites W2075023218 @default.
- W2489562715 cites W2079986203 @default.
- W2489562715 cites W2080064943 @default.
- W2489562715 cites W2081587092 @default.
- W2489562715 cites W2081589050 @default.
- W2489562715 cites W2082905899 @default.
- W2489562715 cites W2082910363 @default.
- W2489562715 cites W2083034193 @default.
- W2489562715 cites W2084887960 @default.
- W2489562715 cites W2086265207 @default.
- W2489562715 cites W2087002642 @default.
- W2489562715 cites W2087783233 @default.
- W2489562715 cites W2089080652 @default.
- W2489562715 cites W2089367177 @default.
- W2489562715 cites W2090018999 @default.
- W2489562715 cites W2091404816 @default.
- W2489562715 cites W2091992164 @default.
- W2489562715 cites W2093702766 @default.
- W2489562715 cites W2093778390 @default.
- W2489562715 cites W2098185447 @default.
- W2489562715 cites W2100047324 @default.
- W2489562715 cites W2102329898 @default.