Matches in SemOpenAlex for { <https://semopenalex.org/work/W2489573075> ?p ?o ?g. }
- W2489573075 endingPage "1719" @default.
- W2489573075 startingPage "1713" @default.
- W2489573075 abstract "Alteration of spontaneous brain activity in COPD patients Jiaxing Zhang,1 Ji Chen,1 Qian Yu,1 Cunxiu Fan,1 Ran Zhang,1 Jianzhong Lin,2 Tianhe Yang,2 Ming Fan3 1Department of Physiology, Medical College of Xiamen University, Xiangan, 2Magnetic Resonance Center, Department of Radiology, Zhongshan Hospital Xiamen University, Xiamen, Fujian, 3Department of Cognitive Sciences, Institute of Basic Medical Sciences, Beijing, People’s Republic of China Background and objective: Airflow limitation in chronic obstructive pulmonary disease (COPD) results in a decrease in oxygen transport to the brain. The aim of the present study was to explore the alteration of spontaneous brain activity induced by hypoxia in patients with COPD. Patients and methods: Twenty-five stable patients with COPD and 25 matching healthy volunteers were investigated. Amplitude of low-frequency fluctuation (ALFF) of blood oxygenation level-dependent signal at resting state in the brain was analyzed using functional magnetic resonance imaging. Results: Whole-brain analysis using functional magnetic resonance imaging revealed significant decreases in ALFF in the bilateral posterior cingulate gyri and right lingual gyrus and an increase in ALFF in the left postcentral gyrus of patients with COPD. After controlling for SaO2, patients with COPD only showed an increase in ALFF in the left postcentral gyrus. Region of interest analysis showed a decrease in ALFF in the left precentral gyrus and an increase in ALFF in the left caudate nucleus of patients with COPD. In all subjects, ALFF in the bilateral posterior cingulate gyri and right lingual gyrus showed positive correlations with visual reproduction. Conclusion: We demonstrated abnormal spontaneous brain activity of patients with COPD, which may have a pathophysiologic meaning. Keywords: chronic obstructive pulmonary disease, hypoxia, low-frequency fluctuation, neuronal activity, resting-state fMRI" @default.
- W2489573075 created "2016-08-23" @default.
- W2489573075 creator A5000337279 @default.
- W2489573075 creator A5014463358 @default.
- W2489573075 creator A5059572081 @default.
- W2489573075 creator A5064404279 @default.
- W2489573075 creator A5075415907 @default.
- W2489573075 creator A5076815748 @default.
- W2489573075 creator A5077094881 @default.
- W2489573075 creator A5078863108 @default.
- W2489573075 date "2016-07-01" @default.
- W2489573075 modified "2023-10-15" @default.
- W2489573075 title "Alteration of spontaneous brain activity in COPD patients" @default.
- W2489573075 cites W108346532 @default.
- W2489573075 cites W1492188804 @default.
- W2489573075 cites W1498139421 @default.
- W2489573075 cites W1507573241 @default.
- W2489573075 cites W1528077233 @default.
- W2489573075 cites W1621169543 @default.
- W2489573075 cites W1708732123 @default.
- W2489573075 cites W1781595368 @default.
- W2489573075 cites W1968382642 @default.
- W2489573075 cites W1970318910 @default.
- W2489573075 cites W1970695058 @default.
- W2489573075 cites W1989795240 @default.
- W2489573075 cites W1990715575 @default.
- W2489573075 cites W1999358054 @default.
- W2489573075 cites W2002562224 @default.
- W2489573075 cites W2009494091 @default.
- W2489573075 cites W2013551728 @default.
- W2489573075 cites W2023614934 @default.
- W2489573075 cites W2036537915 @default.
- W2489573075 cites W2039895323 @default.
- W2489573075 cites W2043283051 @default.
- W2489573075 cites W2045780692 @default.
- W2489573075 cites W2046073222 @default.
- W2489573075 cites W2046104840 @default.
- W2489573075 cites W2058161128 @default.
- W2489573075 cites W2059415755 @default.
- W2489573075 cites W2062145099 @default.
- W2489573075 cites W2069138296 @default.
- W2489573075 cites W2071751092 @default.
- W2489573075 cites W2072481403 @default.
- W2489573075 cites W2078563124 @default.
- W2489573075 cites W2079338730 @default.
- W2489573075 cites W2084850449 @default.
- W2489573075 cites W2086527431 @default.
- W2489573075 cites W2087772676 @default.
- W2489573075 cites W2088355742 @default.
- W2489573075 cites W2090957966 @default.
- W2489573075 cites W2091066178 @default.
- W2489573075 cites W2097872050 @default.
- W2489573075 cites W2104168490 @default.
- W2489573075 cites W2106400335 @default.
- W2489573075 cites W2110827666 @default.
- W2489573075 cites W2116393790 @default.
- W2489573075 cites W2121385822 @default.
- W2489573075 cites W2121544226 @default.
- W2489573075 cites W2121735091 @default.
- W2489573075 cites W2125868297 @default.
- W2489573075 cites W2125892283 @default.
- W2489573075 cites W2131016945 @default.
- W2489573075 cites W2136886754 @default.
- W2489573075 cites W2139553979 @default.
- W2489573075 cites W2142565797 @default.
- W2489573075 cites W2152234748 @default.
- W2489573075 cites W2152249370 @default.
- W2489573075 cites W2158214199 @default.
- W2489573075 cites W2158807672 @default.
- W2489573075 cites W2161502085 @default.
- W2489573075 cites W2163338566 @default.
- W2489573075 cites W2164459098 @default.
- W2489573075 cites W2166367991 @default.
- W2489573075 cites W2170705439 @default.
- W2489573075 cites W2173687125 @default.
- W2489573075 cites W2213869430 @default.
- W2489573075 cites W2239422057 @default.
- W2489573075 cites W2271474800 @default.
- W2489573075 cites W2283674586 @default.
- W2489573075 cites W2312308020 @default.
- W2489573075 cites W2326340583 @default.
- W2489573075 cites W2428878629 @default.
- W2489573075 doi "https://doi.org/10.2147/copd.s110089" @default.
- W2489573075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4968669" @default.
- W2489573075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27555761" @default.
- W2489573075 hasPublicationYear "2016" @default.
- W2489573075 type Work @default.
- W2489573075 sameAs 2489573075 @default.
- W2489573075 citedByCount "13" @default.
- W2489573075 countsByYear W24895730752017 @default.
- W2489573075 countsByYear W24895730752018 @default.
- W2489573075 countsByYear W24895730752019 @default.
- W2489573075 countsByYear W24895730752020 @default.
- W2489573075 countsByYear W24895730752022 @default.
- W2489573075 countsByYear W24895730752023 @default.
- W2489573075 crossrefType "journal-article" @default.
- W2489573075 hasAuthorship W2489573075A5000337279 @default.
- W2489573075 hasAuthorship W2489573075A5014463358 @default.