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- W2489593706 abstract "Previously, we have shown that aqueous cigarette tar (ACT) extracts from mainstream or sidestream cigarette smoke contain a stable radical signal that binds to and damages DNA (deoxyribonucleic acid) in mammalian cells. We have also shown that aged solutions of catechol contain a similar radical signal and cause DNA damage. We have fractionated these ACT solutions and the fractions were analyzed by UV and EPR spectroscopy and GC-MS (Gas Chromatography-Mass Spectrometry). The fractions were also analyzed for DNA nicking activity and only the fractions containing phenolic species (as determined by mass spectroscopy) caused significant DNA damage in rat thymocytes. These DNA damaging fractions also produced hydrogen peroxide, hydroxyl radicals, and superoxide. The tar radicals associate with DNA and cause DNA damage, and this is how cigarette tar may be involved in the toxicity associated with cigarette smoking." @default.
- W2489593706 created "2016-08-23" @default.
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- W2489593706 date "1999-12-20" @default.
- W2489593706 modified "2023-09-25" @default.
- W2489593706 title "Analysis and Fractionation of Cigarette Tar Extracts: What Causes DNA Damage?" @default.
- W2489593706 doi "https://doi.org/10.1021/bk-2000-0745.ch013" @default.
- W2489593706 hasPublicationYear "1999" @default.
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