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- W2489597617 abstract "Small regulatory RNA (sRNA) is responsible for coordination of gene expression network in both prokaryotes and eukaryotes. Some critical genetic regulation circuits in prokaryotes is mostly controlled by the binding of sRNA and the related target mRNA. In this presentation, we analyze the phase space of the synthetic regulatory circuit in Escherichia Coli by utilizing molecular dynamic simulations to calculate their related binding constants. The computed results illustrate a chemostat that allows us to probe various aspects of the sRNA with their related targets. The analysis of the parameter phase regulated by the synthetic circuit also sheds light on possible functional roles of sRNA to indicate the regulatory feedback motifs controlling a large number of biosynthetic operons in bacteria." @default.
- W2489597617 created "2016-08-23" @default.
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- W2489597617 date "2016-02-01" @default.
- W2489597617 modified "2023-10-18" @default.
- W2489597617 title "The Computational Determination of Small RNA Binding Constant to Clarify the Synthetic Regulatory Circuit in Escherichia coli" @default.
- W2489597617 doi "https://doi.org/10.1016/j.bpj.2015.11.1693" @default.
- W2489597617 hasPublicationYear "2016" @default.
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