FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2489678499> ?p ?o ?g. }

• W2489678499 endingPage "1980" @default.
• W2489678499 startingPage "1973" @default.
• W2489678499 abstract "The development of chemoresistance is closely linked to the plateau of the survival rate in osteosarcoma (OS) patients. CD133-positive (CD133+) OS cells are known as cancer stem cells (CSCs) in OS and exhibit the characteristic of chemoresistance. In this study, CD133+ and CD133‑negative (CD133‑) MG‑63 cells were isolated by magnetic activated cell sorting (MACS). We verified that CD133+ MG‑63 cells were more resistant to cisplatin (CDDP) than CD133‑ MG‑63 cells. DNA‑dependent protein kinase catalytic subunit (DNA‑PKcs) and P‑glycoprotein (P‑gp) were expressed at higher levels in the CD133+ MG‑63 cells compared with those levels in the CD133‑ MG‑63 cells, whereas downregulation of DNA‑PKcs by small interfering RNA (siRNA) decreased chemoresistance to CDDP and P‑gp expression at the mRNA and protein levels in these cells. This indicated that DNA‑PKcs was correlated with P‑gp expression in the CD133+ MG‑63 cells. The Akt/NF‑κB pathway was hyperactivated in the CD133+ MG‑63 cells, whereas inhibition of the Akt/NF‑κB pathway downregulated P‑gp expression. In addition, downregulation of DNA‑PKcs suppressed the activity of the Akt/NF‑κB pathway. These results revealed that downregulation of DNA‑PKcs could decrease P‑gp expression via suppression of the Akt/NF‑κB pathway in CD133+ MG‑63 cells. Therefore, inhibition of DNA‑PKcs decreases P‑gp expression and sensitizes OS CSCs to chemotherapeutic agents in vitro, which needs to be further validated in vivo." @default.
• W2489678499 created "2016-08-23" @default.
• W2489678499 creator A5014994716 @default.
• W2489678499 creator A5022526821 @default.
• W2489678499 creator A5034054749 @default.
• W2489678499 creator A5047696180 @default.
• W2489678499 creator A5064142978 @default.
• W2489678499 creator A5074519587 @default.
• W2489678499 date "2016-08-02" @default.
• W2489678499 modified "2023-10-18" @default.
• W2489678499 title "Downregulation of DNA-PKcs suppresses P-gp expression via inhibition of the Akt/NF-κB pathway in CD133-positive osteosarcoma MG-63 cells" @default.
• W2489678499 cites W1485941411 @default.
• W2489678499 cites W1528543854 @default.
• W2489678499 cites W1823890220 @default.
• W2489678499 cites W1912771734 @default.
• W2489678499 cites W1968384480 @default.
• W2489678499 cites W1972372496 @default.
• W2489678499 cites W1974077091 @default.
• W2489678499 cites W1983963726 @default.
• W2489678499 cites W1984878605 @default.
• W2489678499 cites W2002131223 @default.
• W2489678499 cites W2004411620 @default.
• W2489678499 cites W2008922937 @default.
• W2489678499 cites W2010422684 @default.
• W2489678499 cites W2015996393 @default.
• W2489678499 cites W2019173364 @default.
• W2489678499 cites W2025109766 @default.
• W2489678499 cites W2033136493 @default.
• W2489678499 cites W2055931677 @default.
• W2489678499 cites W2061521956 @default.
• W2489678499 cites W2067977005 @default.
• W2489678499 cites W2073067473 @default.
• W2489678499 cites W2086486581 @default.
• W2489678499 cites W2087991548 @default.
• W2489678499 cites W2089735922 @default.
• W2489678499 cites W2105762637 @default.
• W2489678499 cites W2106771830 @default.
• W2489678499 cites W2117692326 @default.
• W2489678499 cites W2126087169 @default.
• W2489678499 cites W2131112855 @default.
• W2489678499 cites W2131909571 @default.
• W2489678499 cites W2136399690 @default.
• W2489678499 cites W2141100586 @default.
• W2489678499 cites W2152987563 @default.
• W2489678499 cites W2163002030 @default.
• W2489678499 cites W2165721913 @default.
• W2489678499 cites W2174811553 @default.
• W2489678499 cites W2189936813 @default.
• W2489678499 cites W2217897699 @default.
• W2489678499 cites W2315607028 @default.
• W2489678499 cites W343229533 @default.
• W2489678499 doi "https://doi.org/10.3892/or.2016.4991" @default.
• W2489678499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27499034" @default.
• W2489678499 hasPublicationYear "2016" @default.
• W2489678499 type Work @default.
• W2489678499 sameAs 2489678499 @default.
• W2489678499 citedByCount "18" @default.
• W2489678499 countsByYear W24896784992017 @default.
• W2489678499 countsByYear W24896784992018 @default.
• W2489678499 countsByYear W24896784992019 @default.
• W2489678499 countsByYear W24896784992020 @default.
• W2489678499 countsByYear W24896784992021 @default.
• W2489678499 countsByYear W24896784992022 @default.
• W2489678499 countsByYear W24896784992023 @default.
• W2489678499 crossrefType "journal-article" @default.
• W2489678499 hasAuthorship W2489678499A5014994716 @default.
• W2489678499 hasAuthorship W2489678499A5022526821 @default.
• W2489678499 hasAuthorship W2489678499A5034054749 @default.
• W2489678499 hasAuthorship W2489678499A5047696180 @default.
• W2489678499 hasAuthorship W2489678499A5064142978 @default.
• W2489678499 hasAuthorship W2489678499A5074519587 @default.
• W2489678499 hasBestOaLocation W24896784991 @default.
• W2489678499 hasConcept C104317684 @default.
• W2489678499 hasConcept C127561419 @default.
• W2489678499 hasConcept C1491633281 @default.
• W2489678499 hasConcept C153911025 @default.
• W2489678499 hasConcept C184235292 @default.
• W2489678499 hasConcept C185592680 @default.
• W2489678499 hasConcept C22615655 @default.
• W2489678499 hasConcept C2781018059 @default.
• W2489678499 hasConcept C29537977 @default.
• W2489678499 hasConcept C502942594 @default.
• W2489678499 hasConcept C54009773 @default.
• W2489678499 hasConcept C54355233 @default.
• W2489678499 hasConcept C55493867 @default.
• W2489678499 hasConcept C62478195 @default.
• W2489678499 hasConcept C68748289 @default.
• W2489678499 hasConcept C75217442 @default.
• W2489678499 hasConcept C81885089 @default.
• W2489678499 hasConcept C86554907 @default.
• W2489678499 hasConcept C86803240 @default.
• W2489678499 hasConcept C95444343 @default.
• W2489678499 hasConcept C97029542 @default.
• W2489678499 hasConceptScore W2489678499C104317684 @default.
• W2489678499 hasConceptScore W2489678499C127561419 @default.
• W2489678499 hasConceptScore W2489678499C1491633281 @default.
• W2489678499 hasConceptScore W2489678499C153911025 @default.
• W2489678499 hasConceptScore W2489678499C184235292 @default.

• next