Matches in SemOpenAlex for { <https://semopenalex.org/work/W2489687568> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2489687568 startingPage "18" @default.
- W2489687568 abstract "iPS cells from patients with kidney disease are a new tool with the potential to impact the future of renal care. They can be used in the laboratory to model the pathophysiology of human kidney disease, and have the potential to establish a new area of immunocompatible, on-demand renal transplantation. Critical challenges remain before the full potential of these cells can be accurately assessed. We need to understand whether the derived cell types are mature and can replace kidney function(s). To what extent can iPS cells model kidney disease in the simplified environment of cell culture? Ultimately, successful integration of these cells as autograft therapies will require demonstration of safety and efficacy equal or superior to the existing gold standards of kidney allograft transplantation and dialysis. Specific educational and infrastructural changes will be necessary if these specialized technologies are to be adopted as an accepted modalities in clinical medicine. Given these barriers, the first fruit of these labors is likely to be improved understanding of pathophysiological pathways in human iPS cell disease models, followed by drug discovery and testing. These experiments will lead naturally to improvements in differentiation and experiments in animal models testing function.The time course to achieve the desired goals remains unknown, but the ultimate hope is that new, more effective and less expensive modalities for renal replacement therapy will occur in the foreseeable future. A new standard of care for patients is anticipated that addresses limitations of currently available treatments." @default.
- W2489687568 created "2016-08-23" @default.
- W2489687568 creator A5088299046 @default.
- W2489687568 creator A5089043211 @default.
- W2489687568 date "2015-08-01" @default.
- W2489687568 modified "2023-09-23" @default.
- W2489687568 title "Stem cells represent a new area of kidney care" @default.
- W2489687568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4918073" @default.
- W2489687568 hasPublicationYear "2015" @default.
- W2489687568 type Work @default.
- W2489687568 sameAs 2489687568 @default.
- W2489687568 citedByCount "0" @default.
- W2489687568 crossrefType "journal-article" @default.
- W2489687568 hasAuthorship W2489687568A5088299046 @default.
- W2489687568 hasAuthorship W2489687568A5089043211 @default.
- W2489687568 hasConcept C126322002 @default.
- W2489687568 hasConcept C141071460 @default.
- W2489687568 hasConcept C142724271 @default.
- W2489687568 hasConcept C144024400 @default.
- W2489687568 hasConcept C177713679 @default.
- W2489687568 hasConcept C2778653478 @default.
- W2489687568 hasConcept C2779134260 @default.
- W2489687568 hasConcept C2779541074 @default.
- W2489687568 hasConcept C2779903281 @default.
- W2489687568 hasConcept C2779978075 @default.
- W2489687568 hasConcept C2780303639 @default.
- W2489687568 hasConcept C2911091166 @default.
- W2489687568 hasConcept C36289849 @default.
- W2489687568 hasConcept C71924100 @default.
- W2489687568 hasConceptScore W2489687568C126322002 @default.
- W2489687568 hasConceptScore W2489687568C141071460 @default.
- W2489687568 hasConceptScore W2489687568C142724271 @default.
- W2489687568 hasConceptScore W2489687568C144024400 @default.
- W2489687568 hasConceptScore W2489687568C177713679 @default.
- W2489687568 hasConceptScore W2489687568C2778653478 @default.
- W2489687568 hasConceptScore W2489687568C2779134260 @default.
- W2489687568 hasConceptScore W2489687568C2779541074 @default.
- W2489687568 hasConceptScore W2489687568C2779903281 @default.
- W2489687568 hasConceptScore W2489687568C2779978075 @default.
- W2489687568 hasConceptScore W2489687568C2780303639 @default.
- W2489687568 hasConceptScore W2489687568C2911091166 @default.
- W2489687568 hasConceptScore W2489687568C36289849 @default.
- W2489687568 hasConceptScore W2489687568C71924100 @default.
- W2489687568 hasIssue "9" @default.
- W2489687568 hasLocation W24896875681 @default.
- W2489687568 hasOpenAccess W2489687568 @default.
- W2489687568 hasPrimaryLocation W24896875681 @default.
- W2489687568 hasRelatedWork W1526530854 @default.
- W2489687568 hasRelatedWork W1968418610 @default.
- W2489687568 hasRelatedWork W1969664479 @default.
- W2489687568 hasRelatedWork W1988222067 @default.
- W2489687568 hasRelatedWork W1991177905 @default.
- W2489687568 hasRelatedWork W1994099119 @default.
- W2489687568 hasRelatedWork W2031838464 @default.
- W2489687568 hasRelatedWork W2071726385 @default.
- W2489687568 hasRelatedWork W2079724129 @default.
- W2489687568 hasRelatedWork W2085567517 @default.
- W2489687568 hasRelatedWork W2085774699 @default.
- W2489687568 hasRelatedWork W2136521018 @default.
- W2489687568 hasRelatedWork W2163766654 @default.
- W2489687568 hasRelatedWork W2339726506 @default.
- W2489687568 hasRelatedWork W2414411621 @default.
- W2489687568 hasRelatedWork W2468244665 @default.
- W2489687568 hasRelatedWork W2740507081 @default.
- W2489687568 hasRelatedWork W2903246167 @default.
- W2489687568 hasRelatedWork W3023740925 @default.
- W2489687568 hasRelatedWork W3202714947 @default.
- W2489687568 hasVolume "29" @default.
- W2489687568 isParatext "false" @default.
- W2489687568 isRetracted "false" @default.
- W2489687568 magId "2489687568" @default.
- W2489687568 workType "article" @default.