FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2489701077> ?p ?o ?g. }

• W2489701077 abstract "Abstract Background This analysis evaluated whether osteoarthritis patients achieving the greatest pain control and lowest pain states also have the greatest improvement in functioning and quality of life. Methods Patients ( n = 419) who failed prior therapies and who were switched to etoricoxib 60 mg were categorized as pain responders or non-responders at 4 weeks based on responder definitions established by the Initiative on Methods, Measurement, and Pain (IMMPACT) criteria, including changes from baseline of ≥15%, ≥30%, ≥50%, ≥70% and a final pain status of ≤3/10 (no worse than mild pain). Pain was assessed at baseline and 4 weeks using 4 questions from the Brief Pain Inventory (BPI) (worst pain, least pain, average pain, and pain right now), and also using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain subscale. We examined the relationship between pain responses with changes from baseline in two functional measures (the BPI Pain Interference questions and the WOMAC Function Subscale) as well as changes from baseline in quality of life (assessed on the SF-36 Physical and Mental Component Summaries). We also sought to understand whether these relationships were influenced by the choice of the pain instrument used to assess response. We contrast the mean difference in improvements in the functional and quality of life instruments based on pain responder status (responder versus non-responder) and the associated 95% confidence limits around this difference. Results Patients with better pain responses were much more likely to have improved functional responses and improved quality of life, with higher mean changes in these outcomes versus pain nonresponders, regardless of the choice of IMMPACT pain response definition (e.g., using any of 15%, 30%, 50%, 70% change from baseline) or the final pain state of ≤3/10. There was an evident gradient, where higher levels of pain response were associated with greater mean improvements in function and quality of life. The finding that greater pain responses led to greater functional improvements and quality of life gains was not dependent on the manner in which pain was evaluated. Five different pain instruments (e.g., the 4 questions on pain from the BPI pain questionnaire and the WOMAC pain subscale) consistently demonstrated that pain responders had statistically significantly greater improvements in function and quality of life compared to pain non-responders. This suggests these results are likely to be generalizable to any validated pain measure for osteoarthritis. Conclusions Pain is an efficient outcome measure for predicting broader patient response in osteoarthritis. Patients who do not achieve timely, acceptable pain states over 4 weeks were less likely to experience functional or quality of life improvements. Implications Good pain improvements in osteoarthritis with a valid pain instrument are a proxy for good improvements in both function and quality of life. Therefore proper osteoarthritis pain assessment can lead to efficient evaluations in the clinic." @default.
• W2489701077 created "2016-08-23" @default.
• W2489701077 creator A5002065340 @default.
• W2489701077 creator A5008285302 @default.
• W2489701077 creator A5029049881 @default.
• W2489701077 creator A5069421572 @default.
• W2489701077 creator A5069610412 @default.
• W2489701077 creator A5085511312 @default.
• W2489701077 creator A5086647439 @default.
• W2489701077 date "2016-10-01" @default.
• W2489701077 modified "2023-09-23" @default.
• W2489701077 title "Osteoarthritis patients with pain improvement are highly likely to also have improved quality of life and functioning. A post hoc analysis of a clinical trial" @default.
• W2489701077 cites W1499773704 @default.
• W2489701077 cites W1914004874 @default.
• W2489701077 cites W1970186596 @default.
• W2489701077 cites W1993447871 @default.
• W2489701077 cites W1995021873 @default.
• W2489701077 cites W1996390771 @default.
• W2489701077 cites W2007511577 @default.
• W2489701077 cites W2021630340 @default.
• W2489701077 cites W2026123588 @default.
• W2489701077 cites W2041644523 @default.
• W2489701077 cites W2056362045 @default.
• W2489701077 cites W2057647525 @default.
• W2489701077 cites W2062548541 @default.
• W2489701077 cites W2076370391 @default.
• W2489701077 cites W2083355677 @default.
• W2489701077 cites W2103600429 @default.
• W2489701077 cites W2122833449 @default.
• W2489701077 cites W2124433729 @default.
• W2489701077 cites W2124471894 @default.
• W2489701077 cites W2124710871 @default.
• W2489701077 cites W2129543954 @default.
• W2489701077 cites W2139969462 @default.
• W2489701077 cites W2157558571 @default.
• W2489701077 cites W2161344815 @default.
• W2489701077 doi "https://doi.org/10.1016/j.sjpain.2016.07.002" @default.
• W2489701077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28850528" @default.
• W2489701077 hasPublicationYear "2016" @default.
• W2489701077 type Work @default.
• W2489701077 sameAs 2489701077 @default.
• W2489701077 citedByCount "8" @default.
• W2489701077 countsByYear W24897010772016 @default.
• W2489701077 countsByYear W24897010772017 @default.
• W2489701077 countsByYear W24897010772018 @default.
• W2489701077 countsByYear W24897010772020 @default.
• W2489701077 countsByYear W24897010772021 @default.
• W2489701077 crossrefType "journal-article" @default.
• W2489701077 hasAuthorship W2489701077A5002065340 @default.
• W2489701077 hasAuthorship W2489701077A5008285302 @default.
• W2489701077 hasAuthorship W2489701077A5029049881 @default.
• W2489701077 hasAuthorship W2489701077A5069421572 @default.
• W2489701077 hasAuthorship W2489701077A5069610412 @default.
• W2489701077 hasAuthorship W2489701077A5085511312 @default.
• W2489701077 hasAuthorship W2489701077A5086647439 @default.
• W2489701077 hasConcept C112143881 @default.
• W2489701077 hasConcept C126322002 @default.
• W2489701077 hasConcept C142724271 @default.
• W2489701077 hasConcept C159110408 @default.
• W2489701077 hasConcept C1862650 @default.
• W2489701077 hasConcept C204787440 @default.
• W2489701077 hasConcept C2776164576 @default.
• W2489701077 hasConcept C2776214540 @default.
• W2489701077 hasConcept C2777831278 @default.
• W2489701077 hasConcept C2779286237 @default.
• W2489701077 hasConcept C2779951463 @default.
• W2489701077 hasConcept C2780052408 @default.
• W2489701077 hasConcept C2781118164 @default.
• W2489701077 hasConcept C44249647 @default.
• W2489701077 hasConcept C67761136 @default.
• W2489701077 hasConcept C71924100 @default.
• W2489701077 hasConcept C99508421 @default.
• W2489701077 hasConceptScore W2489701077C112143881 @default.
• W2489701077 hasConceptScore W2489701077C126322002 @default.
• W2489701077 hasConceptScore W2489701077C142724271 @default.
• W2489701077 hasConceptScore W2489701077C159110408 @default.
• W2489701077 hasConceptScore W2489701077C1862650 @default.
• W2489701077 hasConceptScore W2489701077C204787440 @default.
• W2489701077 hasConceptScore W2489701077C2776164576 @default.
• W2489701077 hasConceptScore W2489701077C2776214540 @default.
• W2489701077 hasConceptScore W2489701077C2777831278 @default.
• W2489701077 hasConceptScore W2489701077C2779286237 @default.
• W2489701077 hasConceptScore W2489701077C2779951463 @default.
• W2489701077 hasConceptScore W2489701077C2780052408 @default.
• W2489701077 hasConceptScore W2489701077C2781118164 @default.
• W2489701077 hasConceptScore W2489701077C44249647 @default.
• W2489701077 hasConceptScore W2489701077C67761136 @default.
• W2489701077 hasConceptScore W2489701077C71924100 @default.
• W2489701077 hasConceptScore W2489701077C99508421 @default.
• W2489701077 hasLocation W24897010771 @default.
• W2489701077 hasOpenAccess W2489701077 @default.
• W2489701077 hasPrimaryLocation W24897010771 @default.
• W2489701077 hasRelatedWork W1552765803 @default.
• W2489701077 hasRelatedWork W1985402024 @default.
• W2489701077 hasRelatedWork W1995021873 @default.
• W2489701077 hasRelatedWork W2024863550 @default.
• W2489701077 hasRelatedWork W2025993340 @default.
• W2489701077 hasRelatedWork W2080911851 @default.
• W2489701077 hasRelatedWork W2132475071 @default.
• W2489701077 hasRelatedWork W2327254568 @default.

• next