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- W2489724356 endingPage "555" @default.
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- W2489724356 abstract "Isoprenoids represent the most diverse natural products family. Their carbon skeleton is formally derived from the branched C5 isoprene skeleton. Two metabolic pathways are utilized by living organisms for synthesizing isopentenyl diphosphate (IPP) and dimethylallyl diphosphate, the universal precursors of this series. In animals, fungi, a few bacteria, and in the cytoplasm of the phototrophic organisms, acetyl coenzyme A and mevalonate (MVA), as the committed intermediate, are the precursors of isoprene units. In most bacteria and in the plastids of phototrophic organisms and related phyla, isoprene units are derived from carbohydrate metabolism. Glyceraldehyde phosphate and pyruvate serve as starting material, leading to methylerythritol phosphate (MEP), the key intermediate of this alternative pathway. In the first issue of this encyclopedia, two chapters were devoted to the discovery of this overlooked metabolic pathway in bacteria and plants. In this second issue, the state of the art on the knowledge of the genes and enzymes of the MVA-independent MEP pathway is presented, with perspectives toward the development of new antimicrobial drugs and the regulation of isoprenoid biosynthesis in plants." @default.
- W2489724356 created "2016-08-23" @default.
- W2489724356 creator A5049292099 @default.
- W2489724356 date "2010-01-01" @default.
- W2489724356 modified "2023-10-18" @default.
- W2489724356 title "Methylerythritol Phosphate Pathway" @default.
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