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- W2489735868 abstract "Clinical experience shows that cancer often presents with a highly variable range of malignancy with different pathological features and prognosis. This heterogeneity is characterised by the progressive loss of the organised properties of differentiated cells, including aspects of growth control, karyotypic stability and tissue structure. Moreover, patient prognosis is often dependent upon the extent of this progression, individuals with well differentiated tumours having a more favourable outlook than those with anaplastic disease. These concepts have major repercussions with regard to the efficient management of cancer, especially where the degree of differentiation within the tumour dictates the type of therapy to be given. Thus in cancers arising from tissues whose normal development and functions are stimulated by hormones, varying degrees of response may be expressed in the tumour population and selectively exploited in their therapy through mechanisms which interfere with hormone production or action." @default.
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- W2489735868 date "1984-01-01" @default.
- W2489735868 modified "2023-09-23" @default.
- W2489735868 title "Biological and clinical aspects of oestrogen receptor measurements in rapidly progressing breast cancer" @default.
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- W2489735868 doi "https://doi.org/10.1007/978-1-349-17615-1_12" @default.
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